Maśliński C, Fogel W A, Wyczółkowska J, Nowak J Z
Arzneimittelforschung. 1986 May;36(5):822-5.
The influence of in vivo tritoqualine (Inhibostamin) given to mice as a single dose (100 mg/kg) or subchronically (40 mg/kg daily for 5 days) has been examined on 1. histamine release from peritoneal mast cells, 2. histamine level in some tissues, and 3. intestinal diamine oxidase activity. The effects of tritoqualine and alpha-hydrazinohistidine injected into eggs on the 16th, 17th or 18th day of chick embryo age on hatching time, histamine level and diamine oxidase (DAO) activity in brood's tissues were also examined. After a single administration of tritoqualine there was a drop of histamine level in brain, a similar tendency being observed in kidney and lung, and an opposite effect in intestine. With the latter coincides the reduced intestinal DAO. Subchronical treatment changes pattern of anti-IgE induced histamine release from mast cells, slightly reduces histamine content in brain, kidney and lung, and transiently increases intestinal DAO. Neither tritoqualine nor alpha-hydrazinohistidine influenced time of hatching. Both drugs differ in respect to direction and intensity of changes they evoke in histamine content and DAO activity in examined organs.
研究了给小鼠单次注射（100毫克/千克）或亚慢性注射（每天40毫克/千克，持续5天）体内曲托喹啉（抑胺素）对以下方面的影响：1. 腹膜肥大细胞组胺释放；2. 某些组织中的组胺水平；3. 肠二胺氧化酶活性。还研究了在鸡胚发育的第16、17或18天向鸡蛋中注射曲托喹啉和α-肼基组氨酸对孵化时间、雏鸡组织中组胺水平和二胺氧化酶（DAO）活性的影响。单次注射曲托喹啉后，脑中组胺水平下降，肾脏和肺中也观察到类似趋势，而肠道中则出现相反作用。后者与肠道DAO降低相吻合。亚慢性治疗改变了抗IgE诱导的肥大细胞组胺释放模式，略微降低了脑、肾和肺中的组胺含量，并短暂增加了肠道DAO。曲托喹啉和α-肼基组氨酸均未影响孵化时间。两种药物在所检测器官中引起的组胺含量和DAO活性变化的方向和强度方面存在差异。
