Biegański T
Acta Physiol Pol. 1983 Jan-Feb;34(1):139-54.
Studies were performed on the distribution and properties of intestinal diamine oxidase (DAO) previously called histaminase. DAO activity is high in the gastrointestinal tract of all investigated species. The highest values are in the aboral part of the small intestine: where DAO is localized in the mucosa, predominantly in the top villus region. A high reaction velocity of human intestinal DAO is observed with putrescine, methylhistamine and histamine. H2 receptor antagonists and an agonist (impromidine) inhibit intestinal DAO. The physiological and pathophysiological significance of intestinal DAO in the regulation of histamine and putrescine levels is described, as is the possibility that DAO may act as a growth retardant.
对先前称为组胺酶的肠道二胺氧化酶（DAO）的分布和特性进行了研究。在所有被研究物种的胃肠道中，DAO活性都很高。最高值出现在小肠的远口部分：DAO定位于黏膜中，主要在绒毛顶部区域。观察到人类肠道DAO对腐胺、甲基组胺和组胺具有较高的反应速度。H2受体拮抗剂和一种激动剂（英普咪定）可抑制肠道DAO。描述了肠道DAO在调节组胺和腐胺水平方面的生理和病理生理意义，以及DAO可能作为生长抑制剂的可能性。
