Bischof P, Herrmann W L, Sizonenko P C
Br J Obstet Gynaecol. 1986 Jun;93(6):600-5. doi: 10.1111/j.1471-0528.1986.tb07962.x.
No changes in PAPP-A levels could be detected when plasma samples were obtained every second day throughout the entire menstrual cycle in three healthy women. But when measured every 30 min throughout 12 consecutive hours, in four healthy women, PAPP-A followed a pulsatile pattern which may originate in the endometrium since no PAPP-A pulses were detected in a long-term hysterectomized woman, or in two men. The pulses were not related to levels of oestradiol, progesterone, FSH or LH.
在三名健康女性的整个月经周期中，每隔一天采集血浆样本，未检测到妊娠相关血浆蛋白A（PAPP-A）水平的变化。但在四名健康女性中，连续12小时每隔30分钟进行测量时，PAPP-A呈现出脉冲式模式，这种模式可能起源于子宫内膜，因为在长期子宫切除的女性或两名男性中未检测到PAPP-A脉冲。这些脉冲与雌二醇、孕酮、促卵泡激素（FSH）或促黄体生成素（LH）的水平无关。
