Bischof P, Duberg S, Schindler A M, Obradovic D, Weil A, Faigaux R, Herrmann W, Sizonenko P C
Br J Obstet Gynaecol. 1982 Sep;89(9):701-3. doi: 10.1111/j.1471-0528.1982.tb05093.x.
Pregnancy-associated plasma protein-A (PAPP-A), oestradiol and progesterone levels have been measured by radioimmunoassay in plasma and in endometrial homogenates of 20 women undergoing hysterectomy. Results were grouped according to the histological stages of the endometrium. In plasma, oestradiol and progesterone concentrations changed from proliferative to secretory stages in the well-established pattern of the menstrual cycle, but PAPP-A levels did not change. In endometrium, oestradiol levels were high during the proliferative stage and low in inactive and secretory endometrium. Endometrial PAPP-A and progesterone concentrations increased from inactive to secretory stages, but only the increase in PAPP-A was statistically significant. A positive correlation observed between endometrial PAPP-A concentrations and plasma oestradiol/progesterone ratio suggests a possible hormonal control for the presence of PAPP-A in the uterus.
采用放射免疫分析法对20例行子宫切除术妇女的血浆和子宫内膜匀浆中的妊娠相关血浆蛋白-A（PAPP-A）、雌二醇和孕酮水平进行了测定。结果根据子宫内膜的组织学分期进行分组。在血浆中，雌二醇和孕酮浓度在月经周期已确定的模式下从增殖期到分泌期发生变化，但PAPP-A水平没有变化。在子宫内膜中，雌二醇水平在增殖期较高，在静止期和分泌期较低。子宫内膜PAPP-A和孕酮浓度从静止期到分泌期增加，但只有PAPP-A的增加具有统计学意义。子宫内膜PAPP-A浓度与血浆雌二醇/孕酮比值之间的正相关表明子宫中PAPP-A的存在可能受激素控制。
