Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida, Kyoto 606-8501, Japan.
Daiichi College of Pharmaceutical Sciences, Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan.
Environ Int. 2014 Feb;63:19-25. doi: 10.1016/j.envint.2013.10.016. Epub 2013 Nov 19.
This study investigated human exposure to neutral, phenolic, and methoxylated organohalogen contaminants (OHCs) in a duplicate diet study to evaluate their concentrations in breast milk and serum of Okinawan people from Japan during 2004-2009. Dietary intakes of phenolic OHCs were predominantly 2,4,6-tribromophenol (TriBP), followed by tetrabromobisphenol A (TBBPA), and 6-hydroxy-2,2',4,4'-tetrabromodiphenyl ether (6-OH-BDE47). After exposure, TriBP and TBBPA were transferred to breast milk, whereas 6-OH-BDE47 was selectively retained in serum. Despite a lower dietary exposure to pentachlorophenol and 4-hydroxy-CB187, both were retained in serum. For the methoxylated OHCs, 2,4,6-tribromoanisole (TriBA) and 6-methoxy-BDE47 were the predominant dietary contaminants, of which TriBA was present in both breast milk and serum, whereas 6-methoxy-BDE47 was selectively transferred to breast milk. These findings suggest that dietary exposure to phenolic and methoxylated OHCs may result in differential partitioning between breast milk and serum with different pharmacokinetic or exposure routes.
本研究通过双份饮食研究调查了人体对中性、酚类和甲氧基有机卤污染物（OHCs）的暴露情况，以评估 2004 年至 2009 年期间日本冲绳人群母乳和血清中这些污染物的浓度。饮食中酚类 OHCs 的摄入量主要为 2,4,6-三溴苯酚（TriBP），其次是四溴双酚 A（TBBPA）和 6-羟基-2,2',4,4'-四溴二苯醚（6-OH-BDE47）。暴露后，TriBP 和 TBBPA 转移到母乳中，而 6-OH-BDE47 则选择性地保留在血清中。尽管五氯苯酚和 4-羟基-CB187 的饮食暴露水平较低，但它们都保留在血清中。对于甲氧基 OHCs，2,4,6-三溴苯甲醚（TriBA）和 6-甲氧基-BDE47 是主要的饮食污染物，其中 TriBA 存在于母乳和血清中，而 6-甲氧基-BDE47 则选择性地转移到母乳中。这些发现表明，饮食中酚类和甲氧基 OHCs 的暴露可能导致母乳和血清之间的不同分配，这与不同的药代动力学或暴露途径有关。
