Hashmi Taqi
Family Medicine Department, King Faisal Specialist Hospital & Research Centre, Jeddah, Saudi Arabia.
BMJ Case Rep. 2011 Sep 13;2011:bcr0420114092. doi: 10.1136/bcr.04.2011.4092.
This is a case report of a 44-year-old obese female who developed subclinical hepatic injury 4 weeks after starting metformin for type 2 diabetes. She had a rise in her alanine aminotransferase which peaked at 5 months (738 U/l) and rapidly declined within days of discontinuing her metformin. No other positive evidence of alternative causes for the hepatic injury was found. The likelihood of metformin-induced injury was 7 on the Naranjo scale of adverse drug reactions. A brief review of the 11 previously reported cases in the English medical literature is also made.
这是一份关于一名44岁肥胖女性的病例报告，该女性在开始使用二甲双胍治疗2型糖尿病4周后出现亚临床肝损伤。她的丙氨酸转氨酶升高，在5个月时达到峰值（738 U/l），在停用二甲双胍后的几天内迅速下降。未发现肝损伤其他替代原因的阳性证据。根据药物不良反应的纳兰霍量表，二甲双胍引起损伤的可能性为7级。本文还简要回顾了英文医学文献中先前报道的11例病例。
