促分泌素对大鼠胰腺中淀粉酶、胰蛋白酶原I和糜蛋白酶原B的mRNA浓度的调节
Regulation of concentrations of mRNA for amylase, trypsinogen I and chymotrypsinogen B in rat pancreas by secretagogues.
作者信息
Renaud W, Giorgi D, Iovanna J, Dagorn J C
出版信息
Biochem J. 1986 Apr 1;235(1):305-8. doi: 10.1042/bj2350305.
Abstract
Regulation of pancreatic gene expression by the secretory stimulants cholecystokinin-pancreozymin, caerulein and pilocarpine was studied in the rat, by using cloned cDNA probes to quantify concentrations of specific mRNAs (amylase, trypsinogen I and chymotrypsinogen B). It is concluded that long-term pancreatic stimulation results in pre-translational regulation of secretory-protein gene expression, with a preferential accumulation of RNA transcripts encoding serine proteinases, compared with that for amylase.
摘要
通过使用克隆的cDNA探针来定量特定mRNA（淀粉酶、胰蛋白酶原I和糜蛋白酶原B）的浓度，研究了分泌刺激剂胆囊收缩素-促胰酶素、蛙皮素和毛果芸香碱对大鼠胰腺基因表达的调节作用。得出的结论是，长期的胰腺刺激导致分泌蛋白基因表达的翻译前调节，与淀粉酶相比，编码丝氨酸蛋白酶的RNA转录本优先积累。
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本文引用的文献
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