儿童期、青少年期、青年期、成年期发生的重度抑郁症的关键特征。
Key Characteristics of Major Depressive Disorder Occurring in Childhood, Adolescence, Emerging Adulthood, Adulthood.
作者信息
Rohde Paul, Lewinsohn Peter M, Klein Daniel N, Seeley John R, Gau Jeff M
机构信息
Oregon Research Institute.
出版信息
Clin Psychol Sci. 2013 Jan;1(1). doi: 10.1177/2167702612457599.
This paper summarizes characteristics of major depressive disorder (MDD) in the Oregon Adolescent Depression Project, using data from 816 participants (56% female; 89% White). Contrasting four developmental periods (Childhood [5-12.9], Adolescence [13-17.9], Emerging Adulthood [18-23.9], Adulthood [24-30]), we examine MDD incidence/recurrence, gender, comorbidity, duration, and suicide attempts across periods. MDD first incidence was lower in Childhood compared to subsequent periods, and higher in Emerging Adulthood than Adulthood. Cumulative incidence was 51%. Recurrence was lower during Childhood than remaining periods, which were comparable. Female gender predicted first incident MDD in all four periods but was unassociated with recurrence. Comorbidity rates were comparable across periods. MDD duration was greater in Childhood than remaining periods. Suicide attempt rates were significantly higher during Adolescence than either Emerging Adulthood or Adulthood. Depression research should focus on MDD during Emerging Adulthood, adolescent suicidal behavior, the continuing role of gender into adulthood, and the ubiquity of MDD.
本文利用来自816名参与者（56%为女性；89%为白人）的数据，总结了俄勒冈青少年抑郁症项目中重度抑郁症（MDD）的特征。通过对比四个发育阶段（儿童期[5 - 12.9岁]、青少年期[13 - 17.9岁]、青年期[18 - 23.9岁]、成年期[24 - 30岁]），我们考察了各阶段的MDD发病率/复发率、性别、共病情况、病程以及自杀未遂情况。儿童期的MDD首次发病率低于后续阶段，青年期高于成年期。累积发病率为51%。儿童期的复发率低于其他阶段，其他阶段的复发率相近。在所有四个阶段中，女性性别都预示着首次发生MDD，但与复发无关。各阶段的共病率相近。儿童期的MDD病程比其他阶段更长。青少年期的自杀未遂率显著高于青年期或成年期。抑郁症研究应关注青年期的MDD、青少年自杀行为、性别在成年期的持续影响以及MDD的普遍性。
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