Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Republic of Korea.
BMC Infect Dis. 2013 Nov 25;13:558. doi: 10.1186/1471-2334-13-558.
This study aimed to elucidate the phenotypic, immunologic, and clinical characteristics of Korean patients with nontuberculous mycobacterial (NTM) lung disease and compare them with non-NTM bronchiectasis (BE) patients.
We prospectively recruited patients between 20 and 80 years of age who had nodular BE type NTM lung disease. Phenotypic, immunologic, and clinical characteristics were evaluated through physical examination, laboratory tests, pulmonary function tests, and radiographic examinations. Questionnaires were also answered. The results of the evaluations were compared with the results of non-NTM BE patients.
A total of 84 patients with NTM lung disease and 47 non-NTM BE patients participated in the study. Mycobacterium avium complex lung disease and M. abscessus lung disease were most common. Patients with NTM lung disease had lower body mass index than non-NTM BE patients. Scoliosis was observed more frequently in patients with NTM lung disease than in non-NTM BE patients.
Significant similarities were seen between Korean patients with NTM lung disease and patients from other countries. Differences in phenotypic and clinical characteristics between NTM lung disease and non-NTM BE patients suggest differences in the immunopathogenesis of NTM lung disease and non-NTM BE.
ClinicalTrials.gov Registration number; NCT01616745.
本研究旨在阐明韩国非结核分枝杆菌（NTM）肺病患者的表型、免疫和临床特征，并将其与非-NTM 支气管扩张症（BE）患者进行比较。
我们前瞻性招募了年龄在 20 至 80 岁之间、有结节性 BE 型 NTM 肺病的患者。通过体格检查、实验室检查、肺功能检查和影像学检查评估表型、免疫和临床特征。还回答了问卷。评估结果与非-NTM BE 患者的结果进行了比较。
共有 84 例 NTM 肺病患者和 47 例非-NTM BE 患者参加了研究。肺疾病最常见的是鸟分枝杆菌复合体和脓肿分枝杆菌。NTM 肺病患者的体重指数低于非-NTM BE 患者。NTM 肺病患者的脊柱侧凸比非-NTM BE 患者更常见。
韩国 NTM 肺病患者与来自其他国家的患者之间存在显著相似性。NTM 肺病和非-NTM BE 患者在表型和临床特征方面的差异表明 NTM 肺病和非-NTM BE 的免疫发病机制不同。
NCT01616745。
