Department of Pharmacy, Federal University of Sergipe, CEP 49100-000 São Cristóvão, Sergipe, Brazil.
Department of Pharmaceutical Sciences, Federal University of Paraíba, CEP 58051-970 João Pessoa, Paraíba, Brazil.
Chemosphere. 2014 Jun;104:37-43. doi: 10.1016/j.chemosphere.2013.10.035. Epub 2013 Nov 22.
The aim of this study was to evaluate the larvicidal activity of Mentha x villosa essential oil (MVEO) and its major constituent, rotundifolone, against larvae of Aedes aegypti. Additionally, a set of 15 analogues of the rotundifolone were evaluated to identify the molecular characteristics which contribute to the larvicidal effect. The results from the present study showed that the MVEO exhibited outstanding toxic effects against Ae. aegypti larvae (LC50=45.0ppm). Rotundifolone exhibited reasonable larvicidal activity (LC50=62.5ppm). With respect to comparative study of rotundifolone and its analogues, all tested compounds were less potent than rotundifolone, except (-)-limonene. In general, replacement of C-C double bonds by epoxides groups decreases the larvicidal potency. The presence of α,β-unsaturated carbonyls contributes to the larvicidal toxicity. The addition of hydroxyl groups in the chemical structure resulted in less potent compounds. Furthermore, the enantioselectivity seems to play an important role for the larvicidal toxicity.
本研究旨在评估薄荷酮（MVEO）及其主要成分罗通定醇对埃及伊蚊幼虫的杀幼虫活性。此外，还评估了一组 15 种罗通定醇类似物，以确定有助于杀幼虫效果的分子特征。本研究结果表明，MVEO 对埃及伊蚊幼虫表现出显著的毒性作用（LC50=45.0ppm）。罗通定醇表现出合理的杀幼虫活性（LC50=62.5ppm）。就罗通定醇及其类似物的比较研究而言，除了（-）-柠檬烯外，所有测试化合物的活性均低于罗通定醇。一般来说，C-C 双键被环氧化物取代会降低杀幼虫活性。α，β-不饱和羰基的存在有助于杀幼虫毒性。在化学结构中添加羟基会导致活性降低的化合物。此外，对映选择性似乎对杀幼虫毒性起着重要作用。
