Smith L J, McCulloch E A, Benchimol S
J Exp Med. 1986 Sep 1;164(3):751-61. doi: 10.1084/jem.164.3.751.
We have investigated whether the p53 oncogene is expressed in the blast cells of patients with acute myeloblastic leukemia. p53 protein was detected in the blast cells of 19 out of 34 patients, but not in normal myelopoietic cells. We find a highly significant correlation between p53 protein synthesis in leukemic blast cells and the secondary plating efficiency of these cells (p = 0.0001). The latter provides an estimate for the self renewal capacity of progenitor cells in the blast population. These data indicate that p53 may be involved in leukemic stem cell renewal.
我们研究了p53癌基因是否在急性髓细胞白血病患者的原始细胞中表达。在34例患者中的19例患者的原始细胞中检测到p53蛋白，但在正常骨髓造血细胞中未检测到。我们发现白血病原始细胞中p53蛋白合成与这些细胞的二次接种效率之间存在高度显著的相关性（p = 0.0001）。后者为原始细胞群中祖细胞的自我更新能力提供了一个估计。这些数据表明p53可能参与白血病干细胞的更新。
