Tanahashi Koichiro, Akazawa Nobuhiko, Miyaki Asako, Choi Youngju, Ra Song-Gyu, Matsubara Tomoko, Kumagai Hiroshi, Oikawa Satoshi, Maeda Seiji
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Am J Hypertens. 2014 Mar;27(3):415-21. doi: 10.1093/ajh/hpt217. Epub 2013 Nov 26.
Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, increase with advancing age and menopausal status. ADMA plays a role in endothelial dysfunction and increasing arterial stiffness. Regular aerobic exercise has a positive effect on arterial function (i.e., arterial compliance). This study investigated the effects of aerobic exercise training on plasma ADMA concentrations and arterial compliance in postmenopausal women.
Thirty postmenopausal women were divided into 2 groups: an exercise group (n = 20) and a control group (n = 10). Subjects in the exercise group completed 12 weeks of aerobic exercise training (65%-80% of maximal heart rate, 40-60 min/day, 3-6 days/week). Before and after each intervention, plasma ADMA concentrations and carotid arterial compliance were measured in all participants.
The baseline plasma ADMA concentrations, carotid arterial compliance, and most other key dependent variables did not differ between the 2 groups. In the exercise group, carotid arterial compliance significantly increased after exercise intervention (P < 0.01), and plasma ADMA concentrations significantly decreased (P < 0.05). In addition, changes in carotid arterial compliance after the exercise intervention were inversely correlated with changes in plasma ADMA concentrations (r = -0.367; P < 0.05).
We demonstrated that aerobic exercise training significantly decreased plasma ADMA concentrations with increase in carotid arterial compliance in postmenopausal women. These results suggest that reduction in ADMA may play an important role in the aerobic exercise training-induced increase in arterial compliance.
不对称二甲基精氨酸（ADMA）是一氧化氮合酶的内源性抑制剂，其水平会随着年龄增长和绝经状态而升高。ADMA在内皮功能障碍和动脉僵硬度增加中起作用。规律的有氧运动对动脉功能（即动脉顺应性）有积极影响。本研究调查了有氧运动训练对绝经后女性血浆ADMA浓度和动脉顺应性的影响。
30名绝经后女性被分为两组：运动组（n = 20）和对照组（n = 10）。运动组的受试者完成了12周的有氧运动训练（最大心率的65%-80%，每天40-60分钟，每周3-6天）。在每次干预前后，测量所有参与者的血浆ADMA浓度和颈动脉顺应性。
两组之间的基线血浆ADMA浓度、颈动脉顺应性以及大多数其他关键因变量没有差异。在运动组中，运动干预后颈动脉顺应性显著增加（P < 0.01），血浆ADMA浓度显著降低（P < 0.05）。此外，运动干预后颈动脉顺应性的变化与血浆ADMA浓度的变化呈负相关（r = -0.367；P < 0.05）。
我们证明，有氧运动训练可显著降低绝经后女性的血浆ADMA浓度，并增加颈动脉顺应性。这些结果表明，ADMA的降低可能在有氧运动训练引起动脉顺应性增加中起重要作用。
