Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan;
Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H348-55. doi: 10.1152/ajpheart.00429.2013. Epub 2013 Dec 6.
The Klotho gene is a suppressor of the aging phenomena, and the secretion as well as the circulation of Klotho proteins decrease with aging. Although habitual exercise has antiaging effects (e.g., a decrease in arterial stiffness), the relationship between Klotho and habitual exercise remains unclear. In the present study, we investigated the effect of habitual exercise on Klotho, with a particular focus on arterial stiffness. First, we examined the correlation between plasma Klotho concentration and arterial stiffness (carotid artery compliance and β-stiffness index) or aerobic exercise capacity [oxygen uptake at ventilatory threshold (VT)] in 69 healthy, postmenopausal women (50-76 years old) by conducting a cross-sectional study. Second, we tested the effects of aerobic exercise training on plasma Klotho concentrations and arterial stiffness. A total of 19 healthy, postmenopausal women (50-76 years old) were divided into two groups: control group and exercise group. The exercise group completed 12 wk of moderate aerobic exercise training. In the cross-sectional study, plasma Klotho concentrations positively correlated with carotid artery compliance and VT and negatively correlated with the β-stiffness index. In the interventional study, aerobic exercise training increased plasma Klotho concentrations and carotid artery compliance and decreased the β-stiffness index. Moreover, the changes in plasma Klotho concentration and arterial stiffness were found to be correlated. These results suggest a possible role for secreted Klotho in the exercise-induced modulation of arterial stiffness.
Klotho 基因是衰老现象的抑制剂，Klotho 蛋白的分泌和循环随着衰老而减少。虽然习惯性运动具有抗衰老作用（例如，动脉僵硬度降低），但 Klotho 与习惯性运动之间的关系尚不清楚。在本研究中，我们研究了习惯性运动对 Klotho 的影响，特别关注动脉僵硬度。首先，我们通过横断面研究，在 69 名健康绝经后妇女（50-76 岁）中，检查了血浆 Klotho 浓度与动脉僵硬度（颈动脉顺应性和β硬度指数）或有氧运动能力[通气阈（VT）时的摄氧量]之间的相关性。其次，我们测试了有氧运动训练对血浆 Klotho 浓度和动脉僵硬度的影响。共有 19 名健康绝经后妇女（50-76 岁）分为两组：对照组和运动组。运动组完成了 12 周的中等强度有氧运动训练。在横断面研究中，血浆 Klotho 浓度与颈动脉顺应性和 VT 呈正相关，与β硬度指数呈负相关。在干预研究中，有氧运动训练增加了血浆 Klotho 浓度和颈动脉顺应性，并降低了β硬度指数。此外，还发现血浆 Klotho 浓度和动脉僵硬度的变化相关。这些结果表明分泌的 Klotho 可能在运动引起的动脉僵硬度调节中起作用。
