Aly Hanan F, Rizk Maha Z, Abo-Elmatty Dina M, Desoky M M, Ibrahim N A, Younis Eman A
Therapeutical Chemistry Department, National Research Center, Cairo, Egypt
Therapeutical Chemistry Department, National Research Center, Cairo, Egypt.
Toxicol Ind Health. 2016 Apr;32(4):753-68. doi: 10.1177/0748233713509428. Epub 2013 Nov 26.
The present work aims to evaluate the protective and ameliorative effects of two plant-derived proteins obtained from the seeds of Cajanus cajan and Caesalpinia gilliesii(Leguminosae) against the toxic effects of acetaminophen in kidney after chronic dose through determination of certain biochemical markers including total urea, creatinine, and kidney marker enzyme, that is, glyceraldehyde-3-phosphate dehydrogenase (GAPDH). In addition histopathological examination of intoxicated and treated kidney with both proteins was performed. The present results show a significant increase in serum total urea and creatinine, while significant decrease in GAPDH. Improvement in all biochemical parameters studied was demonstrated, which was documented by the amelioration signs in rats kidney architecture. Thus, both plant protein extracts can counteract the nephrotoxic process, minimize damage to the kidney, delay disease progression, and reduce its complications.
本研究旨在通过测定某些生化指标，包括总尿素、肌酐和肾脏标记酶即甘油醛-3-磷酸脱氢酶（GAPDH），评估从木豆和刺桐（豆科）种子中获得的两种植物源蛋白对慢性剂量对乙酰氨基酚所致肾脏毒性作用的保护和改善作用。此外，还对用这两种蛋白处理的中毒肾脏进行了组织病理学检查。目前的结果显示血清总尿素和肌酐显著升高，而GAPDH显著降低。研究的所有生化参数均有改善，大鼠肾脏结构的改善迹象证明了这一点。因此，两种植物蛋白提取物均可对抗肾毒性过程，使肾脏损伤最小化，延缓疾病进展并减少其并发症。
