School of Chemical Sciences, University of Science Malaysia, Minden 11800, Penang, Malaysia.
Pharmaceuticals (Basel). 2012 Aug 23;5(8):882-9. doi: 10.3390/ph5080882.
Three isoflavanoids, isovestitol (1), medicarpin (2), and sativan (3), along with another known compound, betulinic acid (4), were isolated from the root of Sesbania grandiflora. The structures of the isolated compounds were characterised by means of spectroscopic techniques (UV, IR, MS, 1H- and 13C-NMR, DEPT, COSY, HMQC, HMBC, and MS analysis). All the tested compounds 1-4 exhibited antituberculosis activity against Mycobacterium tuberculosis H37Rv, with MIC values of 50 µg/mL for compounds 1-3, and 100 µg/mL for compound 4, whereas, the methanol extract exhibited antituberculosis activity of 625 µg/mL. This is the first report on the occurrence of isoflavonoids in this plant and their antituberculosis activity.
从大花草Sesbania grandiflora 的根部分离得到三种异黄酮，异vestitol（1）、 medicarpin（2）和 sativan（3），以及另一种已知化合物白桦脂酸（4）。通过光谱技术（UV、IR、MS、1H 和 13C-NMR、DEPT、COSY、HMQC、HMBC 和 MS 分析）对分离得到的化合物的结构进行了表征。所有测试的化合物 1-4 对结核分枝杆菌 H37Rv 均表现出抗结核活性，化合物 1-3 的 MIC 值为 50 µg/mL，化合物 4 的 MIC 值为 100 µg/mL，而甲醇提取物的抗结核活性为 625 µg/mL。这是首次报道该植物中存在异黄酮及其抗结核活性。
