Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Cancers (Basel). 2010 Jul 14;2(3):1513-27. doi: 10.3390/cancers2031513.
In the past 15 years, invasion of nerves by cancer cells has escaped from its role as a mere bystander in cancer biology and turned into an attractive niche to study the heterotypic interaction between cancer cells and neurons. Today, neural invasion (NI) in pancreatic cancer (PCa) stands out due to the recent demonstration of its association with tumor progression, local recurrence and neuropathic pain. Accordingly, recent research on NI in PCa revealed the critical involvement of numerous nerve- or cancer cell-derived molecules in several novel in vitro and in vivo models of NI, which, however, still need further major improvement.
在过去的 15 年中，癌细胞对神经的侵袭已经摆脱了在癌症生物学中仅仅作为旁观者的角色，转而成为研究癌细胞和神经元异型相互作用的一个有吸引力的研究领域。如今，神经侵袭（NI）在胰腺癌（PCa）中的作用凸显出来，因为最近的研究表明其与肿瘤进展、局部复发和神经性疼痛有关。因此，最近对 PCa 中 NI 的研究揭示了许多神经或癌细胞衍生分子在几种新型 NI 的体外和体内模型中的关键作用，然而，这些模型仍需要进一步的重大改进。
