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Neural crossroads of pancreatic cancer: how nociceptors drive tumor progression and immune evasion.

作者信息

Mota Reyes Carmen, Friess Helmut, Demir Ihsan Ekin

机构信息

Department of Surgery, TUM University Hospital, Klinikum rechts der Isar, Munich, Germany.

Else Kröner Clinician Scientist Professor for Translational Pancreatic Surgery, Technical University of Munich, Munich, Germany.

出版信息

Cell Res. 2025 May 7. doi: 10.1038/s41422-025-01124-5.

DOI:10.1038/s41422-025-01124-5
PMID:40335659
Abstract
摘要

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本文引用的文献

1
Nociceptor neurons promote PDAC progression and cancer pain by interaction with cancer-associated fibroblasts and suppression of natural killer cells.伤害感受器神经元通过与癌症相关成纤维细胞相互作用并抑制自然杀伤细胞来促进胰腺癌进展和癌痛。
Cell Res. 2025 May;35(5):362-380. doi: 10.1038/s41422-025-01098-4. Epub 2025 Mar 24.
2
Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity.组织驻留自然杀伤细胞通过促进cDC1-CD8 T细胞活性来支持胰腺癌的生存。
Elife. 2024 Dec 10;13:RP92672. doi: 10.7554/eLife.92672.
3
Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity.
脾脏中伤害感受器神经元的神经支配促进生发中心反应和体液免疫。
Cell. 2024 Jun 6;187(12):2935-2951.e19. doi: 10.1016/j.cell.2024.04.027. Epub 2024 May 20.
4
Suppression of the antitumoral activity of natural killer cells under indirect coculture with cancer-associated fibroblasts in a pancreatic TIME-on-chip model.在胰腺芯片上的肿瘤免疫微环境模型中,与癌症相关成纤维细胞间接共培养时自然杀伤细胞抗肿瘤活性的抑制。
Cancer Cell Int. 2023 Sep 27;23(1):219. doi: 10.1186/s12935-023-03064-9.
5
Nociceptor neurons affect cancer immunosurveillance.伤害感受器神经元影响癌症免疫监视。
Nature. 2022 Nov;611(7935):405-412. doi: 10.1038/s41586-022-05374-w. Epub 2022 Nov 2.
6
Therapeutic resistance in pancreatic ductal adenocarcinoma: Current challenges and future opportunities.胰腺导管腺癌的治疗抵抗:当前的挑战和未来的机遇。
World J Gastroenterol. 2021 Oct 21;27(39):6527-6550. doi: 10.3748/wjg.v27.i39.6527.
7
Neural control of gut homeostasis.肠道内稳态的神经控制。
Am J Physiol Gastrointest Liver Physiol. 2020 Dec 1;319(6):G718-G732. doi: 10.1152/ajpgi.00293.2020. Epub 2020 Oct 7.
8
Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness.乙酰胆碱通过毒蕈碱受体直接和间接抑制胰腺肿瘤发生和癌症干性。
Cancer Discov. 2018 Nov;8(11):1458-1473. doi: 10.1158/2159-8290.CD-18-0046. Epub 2018 Sep 5.
9
Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer.在胰腺导管腺癌的基因模型中,感觉神经元的消融减缓了癌症的起始和进展。
Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3078-83. doi: 10.1073/pnas.1512603113. Epub 2016 Feb 29.
10
Neural invasion in pancreatic cancer: the past, present and future.胰腺癌中的神经侵犯:过去、现在和未来。
Cancers (Basel). 2010 Jul 14;2(3):1513-27. doi: 10.3390/cancers2031513.