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磁触发双重功能纳米颗粒实现无耐药性凋亡性热疗。

Magnetically triggered dual functional nanoparticles for resistance-free apoptotic hyperthermia.

机构信息

Department of Chemistry, Yonsei University, Seoul 120-749 (Korea).

出版信息

Angew Chem Int Ed Engl. 2013 Dec 2;52(49):13047-51. doi: 10.1002/anie.201306557. Epub 2013 Nov 4.

DOI:10.1002/anie.201306557
PMID:24281889
Abstract

Overcoming resistance: Heat-treated cancer cells possess a protective mechanism for resistance and survival. Resistance-free apoptosis-inducing magnetic nanoparticles (RAINs) successfully promote hyperthermic apoptosis, obstructing cell survival by triggering two functional units of heat generation and the release of geldanamycin (GM) for heat shock protein (Hsp) inhibition under an alternating magnetic field (AMF).

摘要

克服耐药性

热处理的癌细胞具有抵抗和存活的保护机制。无耐药性的凋亡诱导磁性纳米粒子（RAINs）通过在交变磁场（AMF）下触发产热和释放格尔德霉素（GM）这两个功能单元，成功地促进了热诱导凋亡，从而阻断了细胞的存活，抑制了热休克蛋白（Hsp）。

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