National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, 117997 Moscow, Russia.
Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.
Int J Mol Sci. 2019 Jul 28;20(15):3695. doi: 10.3390/ijms20153695.
The proper functioning of the monocyte-macrophage system, an important unit of innate immunity, ensures the normal course of pregnancy. In this review, we present the current data on the origin of the monocyte-macrophage system and its functioning in the female reproductive system during the ovarian cycle, and over the course of both normal and complicated pregnancy. Preeclampsia is a crucial gestation disorder characterized by pronounced inflammation in the maternal body that affects the work of the monocyte-macrophage system. The effects of inflammation at preeclampsia manifest in changes in monocyte counts and their subset composition, and changes in placental macrophage counts and their polarization. Here we summarize the recent data on this issue for both the maternal organism and the fetus. The influence of estrogen on macrophages and their altered levels in preeclampsia are also discussed.
单核细胞-巨噬细胞系统的正常功能是先天免疫的重要单位，它确保了妊娠的正常过程。在这篇综述中，我们介绍了单核细胞-巨噬细胞系统的起源及其在女性生殖系统中的功能，包括在卵巢周期以及正常和复杂妊娠过程中的功能。子痫前期是一种重要的妊娠疾病，其特征是母体明显的炎症反应，影响单核细胞-巨噬细胞系统的功能。子痫前期炎症的影响表现为单核细胞数量及其亚群组成的变化，以及胎盘巨噬细胞数量及其极化的变化。本文总结了母体和胎儿在这方面的最新数据。我们还讨论了雌激素对巨噬细胞的影响及其在子痫前期的改变水平。
