Tubman A, Check J H, Bollendorf A, Wilson C
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA.
Clin Exp Obstet Gynecol. 2013;40(3):315-6.
To determine the confounding effect, if any, of poor motility of sperm that are already compromised by an abnormal hypo-osmotic swelling (HOS) test on pregnancy outcome following in vitro fertilization-embryo transfer (IVF-ET) and intracytoplasmic sperm injection (ICSI).
Clinical and live-delivered pregnancy and implantation rates were retrospectively evaluated in first cycles of couples undergoing IVF-ET with ICSI where the HOS test was < 50% according to deciles of subnormal percentage motility (< 50%) and compared to those with normal motility > or = 50%.
The combination of very poor motility and low HOS test scores did diminish pregnancy rates following IVF with ICSI.
The only part of fertilization of the oocyte that ICSI does not overcome is phase 2 of oocyte activation. Based on these data, the combination of very low percentage motility and low HOS test scores do not adversely affect pregnancy outcome following IVF with ICSI.
确定体外受精-胚胎移植（IVF-ET）和卵胞浆内单精子注射（ICSI）后，异常低渗肿胀（HOS）试验已受损的精子活力差对妊娠结局是否存在混杂效应（若有）。
回顾性评估接受ICSI的IVF-ET夫妇首个周期的临床及活产妊娠率和着床率，根据精子活力低于正常百分比（<50%）的十分位数将HOS试验<50%的情况进行分类，并与精子活力正常（>或=50%）的情况进行比较。
精子活力极差与HOS试验评分低相结合确实会降低ICSI-IVF后的妊娠率。
ICSI无法克服的卵母细胞受精唯一部分是卵母细胞激活的第二阶段。基于这些数据，精子活力极低百分比与HOS试验评分低相结合不会对ICSI-IVF后的妊娠结局产生不利影响。
