a ExxonMobil Biomedical Sciences, Inc. , Annandale , New Jersey.
J Occup Environ Hyg. 2014;11(1):19-31. doi: 10.1080/15459624.2013.831983.
This article describes the IH SkinPerm mathematical tool for estimating dermal absorption. The first part provides the scientific background of the IH SkinPerm model, including the QSARs and the developed differential equations. Then the practical value of the tool is demonstrated through example dermal absorption assessments for substances with skin notations. IH SkinPerm simulates three types of dermal absorption scenarios relevant to occupational environments. The first is dermal absorption from instantaneous splash type exposures onto bare skin for pure liquids. The second estimates dermal absorption from the deposition of pure liquids over time. The third enables estimation of dermal uptake from an airborne vapor concentration. A simulation with IH SkinPerm was made using vapor absorption data published from volunteer exposure studies. Comparison of measured and estimated dermal absorbed dose showed IH SkinPerm estimated dermal absorbed dose was within a factor of 3 compared to the reported study values. IH SkinPerm accounts for substance volatility and evaporated mass and provides real-time description of dermal absorption with graphical displays and numerical outputs. To assess absorption resulting from dermal exposure scenarios, the mass of the substance loaded onto the skin, substance physical chemical properties, exposure duration, and the skin surface area affected are the only required input parameters.
本文介绍了用于估计经皮吸收的 IH SkinPerm 数学工具。第一部分提供了 IH SkinPerm 模型的科学背景，包括定量构效关系和开发的微分方程。然后通过对具有皮肤注释的物质进行示例经皮吸收评估，展示了该工具的实际价值。IH SkinPerm 模拟了与职业环境相关的三种类型的经皮吸收情况。第一种是瞬时飞溅暴露于裸露皮肤上的纯液体的经皮吸收。第二种估计了纯液体随时间的沉积的经皮吸收。第三种能够估计来自空气蒸气浓度的经皮吸收。使用志愿者暴露研究中发表的蒸气吸收数据对 IH SkinPerm 进行了模拟。比较测量值和估计值的经皮吸收剂量表明，与报告的研究值相比，IH SkinPerm 估计的经皮吸收剂量在 3 倍以内。IH SkinPerm 考虑了物质的挥发性和蒸发质量，并通过图形显示和数值输出实时描述经皮吸收。要评估经皮暴露情况下的吸收，唯一需要的输入参数是加载到皮肤上的物质质量、物质物理化学特性、暴露持续时间和受影响的皮肤表面积。
