Service de Neurologie, Hôpital Saint Luc, University of Louvain, Brussels, BelgiumHôpital de la Salpêtrière, Service de neurologie et neuropsychologie, INSERM U289 75651 Paris, FranceService Frédéric Joliot, CEA, Hôpital d'Orsay, 95401 Orsay, FranceLaboratory of Neuroscience, NIH, Bethesda, MD 20892, USAUnité INSERM U320, boulevard Becquerel, 14021 Caen, France.
Eur J Neurol. 1995 Jan;1(3):221-8. doi: 10.1111/j.1468-1331.1995.tb00075.x.
Progressive supranuclear palsy (PSP), a neurodegenerative disease with frontal lobe-like features, shows brain hypometabolism which predominates in frontal cortex, although the most severe histopathological lesions are subcortical. To test the hypothesis of the subcortical origin of the metabolic dysfunction in frontal cortex, we used previously obtained data measured using positron emission tomography (PET) in PSP patients and controls to examine the metabolic links between cortical and subcortical brain regions. We calculated interregional correlations of metabolic values in PSP patients and we compared these values to those obtained in controls. Compared to 20 age-matched controls, the 20 PSP patients studied showed an increase in positive metabolic coupling between frontal and non-frontal cortical regions. There was an abnormal linkage between frontal cortex and thalamus hypometabolism, the latter partly coupled to caudate nucleus hypometabolism. This study suggests a subcortical origin for frontal cortex hypometabolism in which thalamic activity appears to play a pivotal role.
进行性核上性麻痹（PSP）是一种具有额状叶特征的神经退行性疾病，表现为脑代谢低下，主要累及额叶皮质，尽管最严重的组织病理学病变位于皮质下。为了验证皮质下起源于额叶皮质代谢功能障碍的假说，我们使用正电子发射断层扫描（PET）获得的数据来检验 PSP 患者和对照组之间皮质和皮质下脑区之间的代谢联系。我们计算了 PSP 患者皮质间代谢值的相关性，并将这些值与对照组进行了比较。与 20 名年龄匹配的对照组相比，研究中的 20 名 PSP 患者表现出额皮质和非额皮质区域之间代谢正相关的增加。额叶皮质和丘脑代谢低下之间存在异常联系，后者与尾状核代谢低下部分相关。这项研究表明，额叶皮质代谢低下的皮质下起源，其中丘脑活动似乎起着关键作用。
