D'Antona R, Baron J C, Samson Y, Serdaru M, Viader F, Agid Y, Cambier J
Brain. 1985 Sep;108 ( Pt 3):785-99. doi: 10.1093/brain/108.3.785.
The dementia associated with progressive supranuclear palsy (PSP) is considered to be subcortical because the cerebral cortex, unlike the subcortical structures, is usually free from major neuropathological lesions; the characteristic symptoms point to a dysfunction of the prefrontal lobe. The regional cerebral metabolic rate of glucose (rCMR Glu) was studied by positron emission tomography and 18F-fluoro-2-deoxyglucose18FDG in 6 patients presumed to have PSP and was compared with values found in 8 control subjects of similar age. The results obtained showed a highly significant rCMR Glu decrease in the prefrontal cortex of our patients. The loss of several subcortical afferents to prefrontal cortex may be responsible for the frontal cortical hypometabolism present in PSP.
与进行性核上性麻痹（PSP）相关的痴呆被认为是皮质下痴呆，因为与皮质下结构不同，大脑皮质通常没有主要的神经病理病变；其特征性症状指向额叶功能障碍。通过正电子发射断层扫描和18F-氟-2-脱氧葡萄糖（18FDG）对6例疑似患有PSP的患者进行了局部脑葡萄糖代谢率（rCMR Glu）研究，并与8例年龄相仿的对照受试者的值进行了比较。所得结果显示，我们的患者额叶皮质的rCMR Glu显著降低。额叶皮质的几种皮质下传入神经纤维丧失可能是PSP中额叶皮质代谢减退的原因。
