Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
Eur J Neurol. 1995 Sep;2(4):363-7. doi: 10.1111/j.1468-1331.1995.tb00140.x.
A young man presented with generalized chorea as the first manifestation of probable primary antiphospholipid syndrome. He was well till 3 months before admission when he started to have involuntary, choreiform movements involving all extremities, the head and the bulbar muscles. Apart from these movements his physical examination was otherwise unremarkable. Laboratory investigations revealed mild thrombocytopenia, high partial thromboplastin time (PTT) only partially corrected by the addition of normal plasma, false positive syphilis serology, weakly positive antinuclear antibody and a high level of IgG anticardiolipin antibodies. Brain magnetic resonance imaging (MRI) showed multiple scattered small areas of high signal intensity on T2 weighted image in the area of centrum semiovale bilaterally. The patient was started on aspirin and prednisone with rapid symptomatic improvement. Despite the difficulty in proving the association between chorea and the high antiphospholipid antibodies, chorea appears in this case to be the initial symptom of primary antiphospholipid syndrome and we suggest screening for antiphospholipid antibodies in unexplained cases of chorea.
一名年轻男性以全身性舞蹈病为首发表现，可能为原发性抗磷脂综合征。他在入院前 3 个月身体状况良好，开始出现不自主的舞蹈样运动，累及四肢、头部和球部肌肉。除了这些运动外，他的体检无其他异常。实验室检查显示轻度血小板减少，部分凝血活酶时间（PTT）升高，仅部分通过添加正常血浆纠正，梅毒血清学假阳性，抗核抗体弱阳性，IgG 型抗心磷脂抗体水平升高。脑磁共振成像（MRI）显示双侧半卵圆中心区 T2 加权图像上有多个散在的高信号强度小区域。患者开始服用阿司匹林和泼尼松，症状迅速改善。尽管难以证明舞蹈病与高抗磷脂抗体之间存在关联，但在本例中，舞蹈病似乎是原发性抗磷脂综合征的首发症状，我们建议在不明原因的舞蹈病患者中筛查抗磷脂抗体。
