合成 3,4-二苄基四氢呋喃木脂素（9,9'-氧化木脂素）。
Synthesis of 3,4-dibenzyltetrahydrofuran lignans (9,9'-epoxylignanes).
机构信息
Laboratory of Organic Chemistry, Department of Chemistry, P.O. Box 55, FIN-00014, University of Helsinki, Helsinki, 00560, Finland.
出版信息
Molecules. 2013 Oct 24;18(11):13124-38. doi: 10.3390/molecules181113124.
Abstract
Different strategies for the racemic or enantiospecific total syntheses of plant and mammalian 3,4-dibenzyltetrahydrofuran lignans are reviewed and compared. The multi-step approaches have various key step strategies: Diels-Alder reactions, Stobbe condensations, Michael additions, alkylations, nitrile oxide cycloadditions, radical cyclisations, dianion and oxidative couplings.
摘要
不同策略的外消旋或对映选择性全合成植物和哺乳动物 3,4-二苄基四氢呋喃木脂素进行了综述和比较。多步方法具有各种关键步骤策略：Diels-Alder 反应、Stobbe 缩合、迈克尔加成、烷基化、腈氧化物环加成、自由基环化、二阴离子和氧化偶联。
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