科尼亚姆波林，来自科尼亚姆比硼氏菌的首个吡喃并[3,2 - b]吲哚生物碱及其他次生代谢产物。

Koniamborine, the first pyrano[3,2-b]indole alkaloid and other secondary metabolites from Boronella koniambiensis.

作者信息

Grougnet Raphaël, Magiatis Prokopios, Fokialakis Nikolas, Mitaku Sofia, Skaltsounis Alexios-Leandros, Tillequin François, Sévenet Thierry, Litaudon Marc

机构信息

Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens GR-15771, Greece.

出版信息

J Nat Prod. 2005 Jul;68(7):1083-6. doi: 10.1021/np050013w.

DOI:10.1021/np050013w

PMID:16038554

Abstract

Two new alkaloids, (-)-cis-1,2-dihydroxy-1,2-dihydromedicosmine (3) and koniamborine (4), have been isolated from Boronella koniambiensis aerial parts. Their structures have been established from NMR and mass data. Koniamborine is a novel type of alkaloid, which derives from the pyrano[3,2-b]indole basic skeleton, described for the first time from nature. 6-Methoxy-1-methylisatin, also present in the plant material, can be considered biogenetically as a degradation product of the fused pyrone ring of 4.

摘要

从科尼亚姆比硼（Boronella koniambiensis）地上部分分离出了两种新生物碱，(-)-顺式-1,2-二羟基-1,2-二氢美迪考斯明（3）和科尼亚姆比林（4）。它们的结构已通过核磁共振（NMR）和质谱数据确定。科尼亚姆比林是一种新型生物碱，源自吡喃并[3,2 - b]吲哚基本骨架，这是首次从自然界中描述的。植物材料中还存在的6-甲氧基-1-甲基异吲哚酮，从生源论角度可被视为4的稠合吡喃环的降解产物。