Hwang Chung Chew, Mochizuki Masami, Maeda Ken, Okuda Masaru, Mizuno Takuya
Laboratory of Veterinary Internal Medicine, The United Graduate School of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.
J Vet Med Sci. 2014 Mar;76(3):471-5. doi: 10.1292/jvms.13-0472. Epub 2013 Nov 27.
Reovirus infection is common in mammals. However, seroepidemiological data of reovirus neutralizing antibodies are limited in dogs. In this study, sera of 65 healthy dogs from six prefectures across Japan were tested for neutralizing antibodies against reovirus serotype 1 strain Lang (T1L), serotype 2 strain Amy (T2A) and serotype 3 strain Dearing (T3D) using plaque reduction neutralization test (PRNT). Seropositivity against reovirus T1L, T2A and T3D was 53.85%, 33.85% and 46.15%, respectively. Distribution of reovirus seropositive samples displayed no distinguishable geographical pattern. However, reovirus seropositivity increased with age and in dogs housed outdoor. Co-infection of multiple reovirus serotypes in dogs was also detected. These data will provide valuable insights towards the usage of reovirus in oncolytic virotherapy in canine cancers.
呼肠孤病毒感染在哺乳动物中很常见。然而，犬类中呼肠孤病毒中和抗体的血清流行病学数据有限。在本研究中，使用蚀斑减少中和试验（PRNT）检测了来自日本六个县的65只健康犬的血清中针对呼肠孤病毒1型朗株（T1L）、2型艾米株（T2A）和3型迪林株（T3D）的中和抗体。针对呼肠孤病毒T1L、T2A和T3D的血清阳性率分别为53.85%、33.85%和46.15%。呼肠孤病毒血清阳性样本的分布没有明显的地理模式。然而，呼肠孤病毒血清阳性率随年龄增长以及在户外饲养的犬中升高。还检测到犬中多种呼肠孤病毒血清型的共同感染。这些数据将为呼肠孤病毒在犬类癌症溶瘤病毒疗法中的应用提供有价值的见解。
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