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一例罕见的纯睾丸精原细胞瘤，在松果体生殖细胞瘤出现7年后发生。

A rare case of a pure testicular seminoma presenting 7 years after a pineal germinoma.

作者信息

Bhatty Usman Najeeb, Ashrafi Mohammed Hayat, Nicholson Caroline Mary, Haq Ahsanul

机构信息

Urology Department, Lancashire Teaching Hospitals NHS Trust, Sharoe Green Lane, Fulwood, Preston PR2 9HT, UK.

出版信息

Case Rep Urol. 2013;2013:490638. doi: 10.1155/2013/490638. Epub 2013 Oct 10.

DOI:10.1155/2013/490638
PMID:24286014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3810517/
Abstract

Pure testicular seminomas occurring in patients with previous intracranial germ cell tumours are extremely rare. We present such a case. A 37-year-old gentleman presented to urology after previously being treated for a pineal germinoma with steroids and radiotherapy. On routine followup, he described symptoms of a testicular seminoma. This was managed surgically with radical orchidectomy. We discuss the possible causes of such an association with a review of the literature.

摘要

既往有颅内生殖细胞肿瘤的患者发生纯睾丸精原细胞瘤极为罕见。我们报告这样一例病例。一名37岁男性，此前因松果体生殖细胞瘤接受了类固醇和放疗，之后前来泌尿外科就诊。在常规随访中，他描述了睾丸精原细胞瘤的症状。对此进行了根治性睾丸切除术的手术治疗。我们结合文献回顾讨论了这种关联的可能原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3c/3810517/a423bfe0cbcc/CRIM.UROLOGY2013-490638.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3c/3810517/4240ab13537b/CRIM.UROLOGY2013-490638.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3c/3810517/a423bfe0cbcc/CRIM.UROLOGY2013-490638.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3c/3810517/4240ab13537b/CRIM.UROLOGY2013-490638.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3c/3810517/a423bfe0cbcc/CRIM.UROLOGY2013-490638.002.jpg

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引用本文的文献

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本文引用的文献

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Intracranial germ cell tumours. A review with special reference to endocrine manifestations.颅内生殖细胞肿瘤。特别参考内分泌表现的综述。
Acta Oncol. 2012 Jan;51(1):3-9. doi: 10.3109/0284186X.2011.586000.
2
Mixed testicular germ cell tumour in a patient with previous pineal germinoma.患者既往患有松果体生殖细胞瘤，现患有混合性睾丸生殖细胞肿瘤。
J Neurooncol. 2011 Jan;101(1):125-8. doi: 10.1007/s11060-010-0213-x. Epub 2010 May 12.
3
Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature.
体细胞KIT突变主要发生在精原细胞瘤生殖细胞肿瘤中，且不能预测双侧疾病：220例肿瘤报告及文献综述
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Dual occurrence of pineal germinoma and testicular seminoma. Case report and review of the literature.松果体生殖细胞瘤与睾丸精原细胞瘤双发。病例报告及文献复习。
Pediatr Neurosurg. 2006;42(1):38-44. doi: 10.1159/000089508.
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Testicular seminoma 16 years after treatment for CNS germinoma.中枢神经系统生殖细胞瘤治疗16年后发生睾丸精原细胞瘤。
J Neurooncol. 2004 Oct;70(1):83-5. doi: 10.1023/b:neon.0000040829.35787.95.
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Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours.睾丸生殖细胞肿瘤易感性基因定位于Xq27
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Simultaneous presentation of pineal germinoma and testicular seminoma.松果体生殖细胞瘤与睾丸精原细胞瘤同时出现。
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Testicular seminoma in a patient with pineal germinoma.松果体生殖细胞瘤患者合并睾丸精原细胞瘤。
J Clin Pathol. 1994 Aug;47(8):771-2. doi: 10.1136/jcp.47.8.771.
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Changing incidence and geographical distribution of malignant paediatric germ cell tumours in the West Midlands Health Authority region, 1957-92.1957年至1992年西米德兰兹郡卫生局辖区内儿童恶性生殖细胞肿瘤的发病率及地理分布变化
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