Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA; Sections of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA.
Neurogastroenterol Motil. 2014 Feb;26(2):283-9. doi: 10.1111/nmo.12263. Epub 2013 Nov 29.
Most gastroparetic patients are underweight probably because of frequently experienced early satiety, nausea, and vomiting. Some gastroparesis (GP) patients, however, are overweight, for reasons that are not well understood. The aim of this study was to evaluate the factors that influence bodyweight such as resting energy and exercise-related expenditure, symptoms of early satiety, nausea and vomiting, and caloric intake in patients with idiopathic GP and in healthy controls.
Thirty-nine healthy controls and 29 subjects with idiopathic GP were studied. Resting energy expenditure (indirect calorimetry), body composition (bioelectrical impedance), dietary intake (Block Food Frequency Questionnaire), symptoms (Patient Assessment of Upper GI Symptoms), and physical activity (Paffenbarger exercise survey) were assessed.
Both median caloric intake (1242 vs 1804 kcal; p = 0.005) and caloric expenditure (486 vs 2172 kcal; p < 0.01) were significantly lower in patients with GP as compared to controls although BMI (25.8 ± 5.8 vs 24.3 ± 4.0 kg/m²) and resting energy expenditure (1327 ± 293 vs 1422 ± 243 kcal) were similar. On the other hand, the 12 GP patients who had gained weight (GW) since diagnosis had lower symptom severity (12.9 ± 4.4 vs 19.3 ± 6.3; p < 0.05), consumed more calories (1342 vs 1134 kcal; p = 0.08) and expended less calories for activity per week (406 vs 644 median kcal; p = 0.45) compared to the 17 GP patients who had lost weight or remained weight neutral (LW).
CONCLUSIONS & INFERENCES: Patients with GP, although in energy balance, consumed and expended less calories than healthy controls. A subgroup of patients with GP who were less symptomatic, gained weight because of increased caloric intake and reduced energy expenditure.
大多数胃轻瘫患者体重偏轻，可能是因为经常经历早饱、恶心和呕吐。然而，一些胃轻瘫 (GP) 患者超重，原因尚不清楚。本研究旨在评估影响体重的因素，如静息能量和与运动相关的支出、早饱、恶心和呕吐的症状以及热量摄入，这些因素在特发性 GP 患者和健康对照组中有所不同。
研究了 39 名健康对照者和 29 名特发性 GP 患者。评估了静息能量消耗（间接测热法）、身体成分（生物电阻抗）、饮食摄入（Block 食物频率问卷）、症状（上胃肠道症状患者评估）和体力活动（Paffenbarger 运动调查）。
与对照组相比，GP 患者的中位热量摄入（1242 与 1804 kcal；p = 0.005）和热量消耗（486 与 2172 kcal；p < 0.01）均显著较低，尽管 BMI（25.8 ± 5.8 与 24.3 ± 4.0 kg/m²）和静息能量消耗（1327 ± 293 与 1422 ± 243 kcal）相似。另一方面，12 名自诊断以来体重增加（GW）的 GP 患者的症状严重程度较低（12.9 ± 4.4 与 19.3 ± 6.3；p < 0.05），摄入更多的热量（1342 与 1134 kcal；p = 0.08），每周活动消耗的热量较少（406 与中位数 644 kcal；p = 0.45），而 17 名体重减轻或保持体重不变的 GP 患者（LW）。
尽管 GP 患者处于能量平衡状态，但消耗和摄入的热量比健康对照组少。GP 患者中有一部分症状较轻的患者体重增加，原因是热量摄入增加和能量消耗减少。
