特发性胃轻瘫

Idiopathic gastroparesis.

作者信息

Parkman Henry P

机构信息

Gastroenterology Section, Temple University School of Medicine, Parkinson Pavilion 8th Floor, 3401 North Broad Street, Philadelphia, PA 19140, USA.

出版信息

Gastroenterol Clin North Am. 2015 Mar;44(1):59-68. doi: 10.1016/j.gtc.2014.11.015. Epub 2014 Dec 24.

Abstract

Gastroparesis is a chronic symptomatic disorder of the stomach characterized by delayed emptying without evidence of mechanical obstruction. Idiopathic gastroparesis refers to gastroparesis of unknown cause not from diabetes; not from prior gastric surgery; not related to other endocrine, neurologic, rheumatologic causes of gastroparesis; and not related to medications that can delay gastric emptying. There is overlap in the symptoms of idiopathic gastroparesis and functional dyspepsia. Patients with idiopathic gastroparesis often have a constellation of symptoms including nausea, vomiting, early satiety, postprandial fullness, and upper abdominal pain. Current treatment options of dietary management, prokinetics agents, antiemetic agents, and symptom modulators do not adequately address clinical need for idiopathic gastroparesis.

摘要

胃轻瘫是一种慢性症状性胃部疾病,其特征为胃排空延迟且无机械性梗阻证据。特发性胃轻瘫是指病因不明的胃轻瘫,并非由糖尿病引起;不是既往胃部手术所致;与胃轻瘫的其他内分泌、神经、风湿性病因无关;也与可延迟胃排空的药物无关。特发性胃轻瘫和功能性消化不良的症状存在重叠。特发性胃轻瘫患者通常有一系列症状,包括恶心、呕吐、早饱、餐后饱胀和上腹部疼痛。目前的饮食管理、促动力药物、止吐药物和症状调节剂等治疗选择并不能充分满足特发性胃轻瘫的临床需求。

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