Temple University, Philadelphia, PA, USA.
Johns Hopkins University, Baltimore, MD, USA.
Neurogastroenterol Motil. 2021 Feb;33(2):e13974. doi: 10.1111/nmo.13974. Epub 2020 Sep 15.
The classic clinical picture of gastroparesis is a symptomatic patient losing weight. In addition, a number of patients with delayed gastric emptying are obese and/or gaining weight. Our aim was to investigate the factors impacting body weight in patients with idiopathic gastroparesis.
In patients with idiopathic gastroparesis, detailed history and weight were acquired at enrollment and after 48 weeks. Questionnaires assessed symptoms, food intake, physical activity, and quality of life. Patients underwent laboratory testing, gastric emptying scintigraphy, and water load testing.
Of 138 patients with idiopathic gastroparesis, 10% were underweight (BMI < 18.5), 39% were normal weight (BMI 18.5-25), 20% were overweight with BMI 25 to 30 kg/m , and 29% were obese with BMI > 30 kg/m . Body weight at enrollment was positively associated with oral caloric consumption (P < .001), following a gastroparesis diet (P = .04), nutrition consultation (P = .001), upper abdominal pain (P = .01); and negatively associated with energy expenditure (P = .05), alcohol use (P = .003) and severity of bloating (P < .001). When followed over 48 weeks, 53% patients stayed stable (within 5% of baseline weight), 30% gained, and 17% lost weight. Weight gain over 48 weeks was positively associated with oral caloric consumption (P = .003) and constipation severity (P = .005) at enrollment, and negatively associated with lower abdominal pain severity (P = .007) at enrollment, and associated with improvement in inability to finish meal score (P < .001) at 48 weeks.
In this series of patients with idiopathic gastroparesis, 10% were underweight whereas 29% were obese. Over 48 weeks, 30% of patients increased their body weight ≥ 5%. Diet, activity, and symptoms are important factors associated with body weight in patients with idiopathic gastroparesis.
胃轻瘫的典型临床表现是症状性患者体重减轻。此外，许多胃排空延迟的患者肥胖和/或体重增加。我们的目的是研究影响特发性胃轻瘫患者体重的因素。
在特发性胃轻瘫患者中，在入组时和 48 周后获取详细的病史和体重。问卷调查评估症状、食物摄入、体力活动和生活质量。患者接受实验室检查、胃排空闪烁扫描和水负荷试验。
在 138 例特发性胃轻瘫患者中，10%为体重不足（BMI<18.5），39%为正常体重（BMI 18.5-25），20%为超重（BMI 25-30kg/m²），29%为肥胖（BMI>30kg/m²）。入组时的体重与口服热量摄入呈正相关（P<0.001），遵循胃轻瘫饮食（P=0.04）、营养咨询（P=0.001）、上腹痛（P=0.01）；与能量消耗呈负相关（P=0.05）、饮酒（P=0.003）和腹胀严重程度呈负相关（P<0.001）。随访 48 周时，53%的患者体重稳定（在基线体重的 5%以内），30%的患者体重增加，17%的患者体重减轻。48 周时体重增加与入组时口服热量摄入（P=0.003）和便秘严重程度（P=0.005）呈正相关，与入组时下腹痛严重程度（P=0.007）呈负相关，与不能完成膳食评分的改善呈正相关（P<0.001）。
在这一系列特发性胃轻瘫患者中，10%的患者体重不足，而 29%的患者肥胖。在 48 周内，30%的患者体重增加≥5%。饮食、活动和症状是特发性胃轻瘫患者体重的重要相关因素。
