Visser G W, Zwaagstra O, Gorree G C, Moonen P, Herscheid J D, Hoekstra A
Eur J Nucl Med. 1986;12(3):137-40. doi: 10.1007/BF00276706.
[18F]-5-fluorocytosine-arabinoside (2) and [18F]-5-fluorocyclocytidine (4) were prepared by reaction of [18F]-acetylhypofluorite with cytosine-arabinoside (1) or cyclocytidine (3) in acetic acid and were isolated in an overall radiochemical yield of 20% and 9%, respectively. The biodistribution of both radiopharmaceuticals was determined in melanoma bearing Syrian golden hamsters. It was found that 2 is a good tumour-localizing agent for pigmented and non-pigmented Greene melanoma.
[18F]-5-氟胞嘧啶阿拉伯糖苷（2）和[18F]-5-氟环胞苷（4）是通过[18F]-乙酰次氟酸与胞嘧啶阿拉伯糖苷（1）或环胞苷（3）在乙酸中反应制备的，其总放射化学产率分别为20%和9%。在携带黑色素瘤的叙利亚金仓鼠中测定了这两种放射性药物的生物分布。结果发现，2是一种对色素沉着和非色素沉着的格林黑色素瘤均有效的肿瘤定位剂。
