Turner J H, Maziere M, Comar D
Eur J Nucl Med. 1985;10(9-10):392-7. doi: 10.1007/BF00256577.
Seventy Syrian golden hamsters bearing SC transplants of Greene melanoma were used to evaluate the degree of tumour uptake of several 11C-radiopharmaceuticals selected for their potential specificity for melanoma. Tissue distribution studies were performed at 30 and 60 min after IV injection of 11C-compounds and compared with the 24-h uptake of 67Ga-citrate. Gamma camera images were also compared. The highest tumour uptake at 1 h was observed with 11C-methionine (2.42% +/- 0.72%) and although activity in liver, spleen and kidney exceeded that in melanoma the tumour was demonstrated on gamma camera imaging. Melanoma localisation of 11C-chlorpromazine, 11C-flunitrazepam and 11C-ketanserine was comparable at 1% of the dose injected per gram of tumour. High activity in other organs, particularly liver, exceeded uptake in melanoma and attempts at tumour imaging were unsuccessful. Tumour accumulation of 11C-methiodide quinuclidinyl benzylate (MQNB), an 11C-imidazobenzodiazepine (Ro-15-1788) and 14C-pimozide was low and imaging studies were not attempted. None of the 11C-radiopharmaceuticals evaluated for melanoma affinity matched that of 67Ga-citrate. The 24-h tumour uptake of 67Ga-citrate was 4.07% +/- 1.37% dose injected per gram which allowed delineation of the melanoma by gamma camera imaging.
选用70只皮下移植了格林黑色素瘤的叙利亚金黄地鼠，以评估几种因对黑色素瘤具有潜在特异性而挑选出的11C放射性药物的肿瘤摄取程度。在静脉注射11C化合物后30分钟和60分钟进行组织分布研究，并与67Ga枸橼酸盐的24小时摄取情况进行比较。还比较了γ相机图像。11C-蛋氨酸在1小时时肿瘤摄取最高（2.42%±0.72%），尽管肝脏、脾脏和肾脏中的活性超过黑色素瘤，但在γ相机成像中仍可显示出肿瘤。11C-氯丙嗪、11C-氟硝西泮和11C-酮色林在黑色素瘤中的定位相当，每克肿瘤摄取量为注射剂量的1%。其他器官，特别是肝脏中的高活性超过了黑色素瘤中的摄取，肿瘤成像尝试未成功。11C-甲基碘化奎宁环苄酯（MQNB）、一种11C-咪唑并苯二氮䓬（Ro-15-1788）和14C-匹莫齐特在肿瘤中的蓄积较低，未进行成像研究。所评估的用于黑色素瘤亲和力的11C放射性药物均无法与67Ga枸橼酸盐相匹配。67Ga枸橼酸盐在24小时时每克肿瘤的摄取量为注射剂量的4.07%±1.37%，这使得γ相机成像能够勾勒出黑色素瘤的轮廓。
