Wunsch Alexander, Matuschka Karsten
1 Medical Light Consulting , Heidelberg, Germany .
Photomed Laser Surg. 2014 Feb;32(2):93-100. doi: 10.1089/pho.2013.3616. Epub 2013 Nov 28.
The purpose of this study was to investigate the safety and efficacy of two novel light sources for large area and full body application, providing polychromatic, non-thermal photobiomodulation (PBM) for improving skin feeling and appearance.
For non-thermal photorejuvenation, laser and LED light sources have been demonstrated to be safe and effective. However, lasers and LEDs may offer some disadvantages because of dot-shaped (punctiform) emission characteristics and their narrow spectral bandwidths. Because the action spectra for tissue regeneration and repair consist of more than one wavelength, we investigated if it is favorable to apply a polychromatic spectrum covering a broader spectral region for skin rejuvenation and repair.
A total of 136 volunteers participated in this prospective, randomized, and controlled study. Of these volunteers, 113 subjects randomly assigned into four treatment groups were treated twice a week with either 611-650 or 570-850 nm polychromatic light (normalized to ∼ 9 J/cm(2) in the range of 611-650 nm) and were compared with controls (n=23). Irradiances and treatment durations varied in all treatment groups. The data collected at baseline and after 30 sessions included blinded evaluations of clinical photography, ultrasonographic collagen density measurements, computerized digital profilometry, and an assessment of patient satisfaction.
The treated subjects experienced significantly improved skin complexion and skin feeling, profilometrically assessed skin roughness, and ultrasonographically measured collagen density. The blinded clinical evaluation of photographs confirmed significant improvement in the intervention groups compared with the control.
Broadband polychromatic PBM showed no advantage over the red-light-only spectrum. However, both novel light sources that have not been previously used for PBM have demonstrated efficacy and safety for skin rejuvenation and intradermal collagen increase when compared with controls.
本研究旨在调查两种新型光源用于大面积全身照射的安全性和有效性，提供多色、非热光生物调节（PBM）以改善皮肤感觉和外观。
对于非热光嫩肤，激光和发光二极管（LED）光源已被证明是安全有效的。然而，由于点状发射特性和窄光谱带宽，激光和LED可能存在一些缺点。由于组织再生和修复的作用光谱由多个波长组成，我们研究了应用覆盖更宽光谱区域的多色光谱进行皮肤年轻化和修复是否有利。
共有136名志愿者参与了这项前瞻性、随机对照研究。在这些志愿者中，113名随机分为四个治疗组的受试者每周接受两次611 - 650或570 - 850 nm多色光治疗（在611 - 650 nm范围内归一化为约9 J/cm²），并与对照组（n = 23）进行比较。所有治疗组的辐照度和治疗持续时间各不相同。在基线和30次治疗后收集的数据包括临床照片的盲法评估、超声胶原密度测量、计算机化数字轮廓测量以及患者满意度评估。
接受治疗的受试者在皮肤色泽、皮肤感觉、轮廓测量评估的皮肤粗糙度以及超声测量的胶原密度方面均有显著改善。照片的盲法临床评估证实，与对照组相比，干预组有显著改善。
宽带多色PBM与仅红光光谱相比没有优势。然而，与对照组相比，这两种以前未用于PBM的新型光源在皮肤年轻化和真皮内胶原增加方面均显示出有效性和安全性。
