Student, Faculty of Medicine, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Romania.
Clin Cosmet Investig Dermatol. 2012;5:7-13. doi: 10.2147/CCID.S25840. Epub 2012 Jan 10.
Ultrasonography allows the quantification of dermal density and echogenicity changes during the physiological senescence process. Some active ingredients are able to slow down the tissular degeneration and disorganization process. The purpose of this study was to assess the cutaneous changes induced by the topical use of products containing Viniferol(®) as active ingredient, using high-frequency ultrasound. The study was performed over 12 weeks and included 80 healthy Caucasian female subjects, aged 22-75 years, divided into two groups: the study group and the control group. The product was applied according to a predetermined protocol. The measurements performed for each subject were: the thickness of the epidermis and dermis (mm), the number of low, medium, and high echogenic pixels, and the number of low echogenic pixels in the upper dermis/number of low echogenic pixels in the lower dermis. All the parameters showed a significant improvement. Ultrasound measurements showed an increase of the mean thickness of the epidermis (P < 0.0001) and dermis (P < 0.0001) following the application of the Viniferol product as compared to the control group. The changes in the dermal echogenicity confirm the efficacy and direct action of Viniferol upon the cutaneous fibroblasts. No side effects related to the treatment were recorded. The study proves the efficacy of this active ingredient in the cutaneous senescence process as well, as the fact that anti-aging prophylaxis should be initiated in the 20-40 year critical age group. This interval involves specific changes in dermal echogenicity that quantify intense molecular, biochemical and structural changes, being thus mostly and highly responsive to the anti-aging therapy.
超声检查可定量评估生理衰老过程中皮肤密度和超声回声的变化。某些活性成分能够减缓组织退化和紊乱过程。本研究旨在使用高频超声评估含有 Viniferol（®）作为活性成分的局部用产品引起的皮肤变化。该研究进行了 12 周，包括 80 名健康的高加索女性，年龄在 22-75 岁之间，分为两组：研究组和对照组。按照预定方案使用产品。对每位受试者进行的测量包括：表皮和真皮的厚度（mm）、低、中、高回声像素的数量以及上真皮中的低回声像素数量/下真皮中的低回声像素数量。所有参数均显示出显著改善。超声测量显示，与对照组相比，Viniferol 产品应用后表皮（P < 0.0001）和真皮（P < 0.0001）的平均厚度均增加。真皮回声的变化证实了 Viniferol 对皮肤成纤维细胞的疗效和直接作用。未记录到与治疗相关的副作用。该研究证明了该活性成分在皮肤衰老过程中的功效，因为在 20-40 岁的关键年龄段就应该开始进行抗衰老预防。这一间隔涉及到真皮回声的特定变化，这些变化量化了剧烈的分子、生化和结构变化，因此对抗衰老治疗的反应最为敏感和强烈。
