Department of Clinical Analysis, Centre for Health Sciences, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Planta Med. 2013 Nov;79(17):1605-14. doi: 10.1055/s-0033-1351018. Epub 2013 Nov 28.
Rosmarinus officinalis, also named rosemary, is a native plant from the Mediterranean region that is useful for the treatment of inflammatory diseases. Studies using experimental models and/or in vitro tests have shown the important biological effects of rosemary. In this context, the mechanism of the anti-inflammatory activity of rosemary must be investigated to support the discovery of new substances with anti-inflammatory effects. The aim of the present study was to investigate the anti-inflammatory effects of crude extract oil free obtained from the leaves of rosemary in an animal model of inflammation, thus evaluating its medicinal use for the treatment of inflammatory conditions. Also its ethanol, hexane, and ethyl acetate fractions, as well as its isolated compounds carnosol and rosmarinic acid were analyzed. Swiss mice were used for the in vivo experiments. The effect of this herb on the inhibition of the leukocytes, exudation, myeloperoxidase, and adenosine-deaminase activities, nitrite/nitrate, interleukin 17A, and interleukin 10 levels and mRNA expression was determined. The crude extract and its derived fractions, in addition to its isolated compounds, inhibited leukocytes and decreased exudation and myeloperoxidase and adenosine-deaminase activities, as well as nitrite/nitrate and interleukin 17A levels and mRNA expression, besides increasing interleukin 10 levels and mRNA expression. Rosemary showed important anti-inflammatory activity by inhibiting leukocytes and decreasing exudation. These effects were associated with a decrease in the proinflammatory parameters (myeloperoxidase, adenosine-deaminase, nitrite/nitrate, and interleukin 17A) and an increase in the anti-inflammatory cytokine (interleukin 10). This study confirms the anti-inflammatory properties of rosemary and validates its use in folk medicine to treat inflammatory diseases such as rheumatism and asthma.
迷迭香，也称为迷迭香，是一种原产于地中海地区的植物，可用于治疗炎症性疾病。使用实验模型和/或体外试验的研究表明了迷迭香的重要生物学效应。在这种情况下，必须研究迷迭香抗炎活性的机制，以支持发现具有抗炎作用的新物质。本研究的目的是研究从迷迭香叶中获得的无油粗提物在炎症动物模型中的抗炎作用，从而评估其在治疗炎症性疾病方面的药用价值。还分析了其乙醇、己烷和乙酸乙酯馏分以及其分离化合物鼠尾草酸和迷迭香酸。使用瑞士小鼠进行体内实验。研究了这种草药对白细胞抑制、渗出、髓过氧化物酶和腺苷脱氨酶活性、亚硝酸盐/硝酸盐、白细胞介素 17A 和白细胞介素 10 水平和 mRNA 表达的影响。粗提物及其衍生的馏分，以及其分离的化合物，抑制白细胞并减少渗出物和髓过氧化物酶和腺苷脱氨酶活性，以及亚硝酸盐/硝酸盐和白细胞介素 17A 水平和 mRNA 表达，同时增加白细胞介素 10 水平和 mRNA 表达。迷迭香通过抑制白细胞和减少渗出物表现出重要的抗炎活性。这些作用与促炎参数（髓过氧化物酶、腺苷脱氨酶、亚硝酸盐/硝酸盐和白细胞介素 17A）的降低和抗炎细胞因子（白细胞介素 10）的增加有关。这项研究证实了迷迭香的抗炎特性，并验证了其在民间医学中用于治疗风湿和哮喘等炎症性疾病的用途。
