H&TRC-Health and Technology Research Center, ESTeSL-Lisbon School of Health Technology, Instituto Politécnico de Lisboa, 1990-096 Lisbon, Portugal.
Molecules. 2022 Jan 18;27(3):609. doi: 10.3390/molecules27030609.
This systematic review aimed to evaluate the potential anti-inflammatory effect of in preclinical in vivo models of inflammation. A search was conducted in the databases PubMed, Scopus, and Web of Science, with related keywords. The inclusion criteria were inflammation, plant, and studies on rats or mice; while, the exclusion criteria were reviews, studies with in vitro models, and associated plants. The predominant animal models were paw edema, acute liver injury, and asthma. Rosemary was more commonly used in its entirety than in compounds, and the prevalent methods of extraction were maceration and hydrodistillation. The most common routes of administration reported were gavage, intraperitoneal, and oral, on a route-dependent dosage. Treatment took place daily, or was single-dose, on average for 21 days, and it more often started before the induction. The most evaluated biomarkers were tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10, myeloperoxidase (MPO), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), malondialdehyde (MDA), and superoxide dismutase (SOD). The best results emerged at a dose of 60 mg/kg, via IP of carnosic acid, a dose of 400 mg/kg via gavage of , and a dose of 10 mg/kg via IP of rosmarinic acid. L. showed anti-inflammatory activity before and after induction of treatments.
本系统评价旨在评估 在炎症的临床前动物模型中的潜在抗炎作用。在 PubMed、Scopus 和 Web of Science 数据库中使用相关关键词进行了检索。纳入标准为炎症、植物以及大鼠或小鼠的研究；而排除标准为综述、体外模型研究以及相关植物。主要的动物模型为足爪肿胀、急性肝损伤和哮喘。迷迭香通常以全草形式而不是化合物形式使用，常见的提取方法为浸渍法和水蒸馏法。报告的最常见给药途径为灌胃、腹腔内和口服，剂量取决于给药途径。治疗通常每天进行，或为单次剂量，平均持续 21 天，并且通常在诱导前开始。评估的最常见生物标志物为肿瘤坏死因子 (TNF)-α、白细胞介素 (IL)-1β、IL-6、IL-10、髓过氧化物酶 (MPO)、过氧化氢酶 (CAT)、谷胱甘肽 (GSH)、谷胱甘肽过氧化物酶 (GPx)、丙二醛 (MDA)和超氧化物歧化酶 (SOD)。最佳结果出现在通过腹腔内注射 carnosic 酸 60mg/kg、通过灌胃 400mg/kg 以及通过腹腔内注射 rosmarinic 酸 10mg/kg 的剂量下。 L. 在治疗诱导前后均显示出抗炎活性。
