Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou, People's Republic of China.
State Key Laboratory for Respiratory Disease, Laboratory of Viral Immunology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China.
Planta Med. 2013 Dec;79(18):1742-8. doi: 10.1055/s-0033-1351051. Epub 2013 Nov 28.
This paper reports the phytochemical investigation of the 50% aq. EtOH extract of Houttuynia cordata, an effective TCM and functional food in China, which led to the isolation of 17 flavonoids including four new ones. The four new compounds were flavonoid derivatives tethered with houttuynin (3-oxododecanal). Each of the new compounds was obtained as a pair of inseparable diasteriomeric epimers due to the chiral carbon of hemiketal at C-3″. This phenomenon is rooted in the ring-chain tautomerism of the hemiketal functional group in solution, which was proved by dynamic NMR experiments. The new compounds 1-4 displayed inhibitory activities against herpes simplex virus 1, with respective IC50 values of 38.46, 14.10, 62.00 and 70.76 µM, which was associated with the medicinal functions of H. cordata.
本文报道了中国一种有效的中药和功能性食品鱼腥草的 50%水乙醇提取物的化学成分研究，从中分离得到了 17 种黄酮类化合物，包括 4 种新化合物。这 4 种新化合物是与鱼腥草素（3-氧代十二醛）连接的黄酮类衍生物。由于 C-3″位半缩醛的手性碳原子，每个新化合物都以一对不可分离的非对映异构体形式存在。这种现象源于半缩醛官能团在溶液中的环链互变异构，这通过动态 NMR 实验得到了证明。新化合物 1-4 对单纯疱疹病毒 1 显示出抑制活性，IC50 值分别为 38.46、14.10、62.00 和 70.76µM，这与鱼腥草的药用功能有关。
