Li Jiao-Jiao, Chen Guo-Dong, Fan Hong-Xia, Hu Dan, Zhou Zheng-Qun, Lan Kang-Hua, Zhang Hui-Ping, Maeda Hideaki, Yao Xin-Sheng, Gao Hao
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University , Guangzhou 510632, People's Republic of China.
RIKEN Center for Life Science Technologies , Yokohama, Kanagawa 2300045, Japan.
J Nat Prod. 2017 Nov 22;80(11):3010-3013. doi: 10.1021/acs.jnatprod.7b00620. Epub 2017 Nov 3.
Houttuynoid M (1), a new houttuynoid, and the related known compound houttuynoid A (2) were isolated from Houttuynia cordata. Their structures were defined using NMR data analysis, HR-MS experiment, and chemical derivatization. Houttuynoid M is the first example of a houttuynoid with a bis-houttuynin chain tethered to a flavonoid core. A putative biosynthetic pathway of houttuynoid M (1) is proposed. The anti-herpes simplex virus (anti-HSV) activities of 1 and 2 (IC values of 17.72 and 12.42 μM, respectively) were evaluated using a plaque formation assay with acyclovir as the positive control.
从鱼腥草中分离出了一种新的鱼腥草素类化合物——鱼腥草素M（1）以及相关的已知化合物鱼腥草素A（2）。通过核磁共振数据分析、高分辨质谱实验和化学衍生化确定了它们的结构。鱼腥草素M是首例具有连接到黄酮类核心的双鱼腥草素链的鱼腥草素类化合物。提出了鱼腥草素M（1）可能的生物合成途径。以阿昔洛韦作为阳性对照，采用蚀斑形成试验评估了1和2的抗单纯疱疹病毒（抗HSV）活性（IC值分别为17.72和12.42 μM）。
