来自天仙藤的具有生物活性的苯并呋喃新木脂素。
Bioactive benzofuran neolignans from Aristolochia fordiana.
机构信息
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, PR China.
出版信息
Planta Med. 2013 Dec;79(18):1730-5. doi: 10.1055/s-0033-1351100. Epub 2013 Nov 28.
Six new benzofuran neolignans (1-6) were isolated from the EtOAc-soluble fraction of the aerial part of Aristolochia fordiana, together with twelve known analogues (7-18). The structures of the isolated compounds were elucidated by spectroscopic methods. All isolates were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccaride-activated RAW264.7 macrophages and for their cytotoxic activities on three human cancer cell lines. Compound 2 showed significant nitric oxide production inhibitory activity with an IC50 value of 10.00 µM, while compound 16 exhibited cytotoxic activity with an IC50 value of 11.9 µM against MG-63 and compound 18 of 9.15 µM against HepG2 cell lines, respectively.
从马兜铃科细辛属植物土木香的乙酸乙酯可溶部分中分离得到了 6 个新的苯并呋喃新木脂素（1-6），并与 12 个已知类似物（7-18）一起分离得到。通过光谱方法阐明了分离化合物的结构。所有分离物均进行了抑制脂多糖激活的 RAW264.7 巨噬细胞中一氧化氮产生的抑制活性以及对三种人癌细胞系的细胞毒性活性的评价。化合物 2 对一氧化氮的产生具有显著的抑制活性，IC50 值为 10.00 µM，而化合物 16 对 MG-63 的细胞毒性活性，IC50 值为 11.9 µM，化合物 18 对 HepG2 细胞系的细胞毒性活性，IC50 值为 9.15 µM。
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