Ostrea Enrique M, Villanueva-Uy Esterlita, Bielawski Dawn, Birn Sarah, Janisse James J
Department of Pediatrics, Hutzel Women's Hospital, the Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, MI, USA.
J Bioanal Biomed. 2011 Nov 16;4. doi: 10.4172/1948-593X.1000057.
BACKGROUND/AIM: The long term study of the adverse effects of pesticides on child neuro development requires monitoring not only of initial, but ongoing pesticide exposure. Our aim was to compare house dust and children's hair as environmental and biological markers of ongoing pesticide exposure in children.
DESIGN/METHODS: In a continuing NIH study on the adverse effects of prenatal pesticide exposure on child neurodevelopment, ongoing pesticide exposure after birth was measured in swept house dust and hair in the children at 4 years of age for propoxur and pyrethroids (transfluthrin, bioallethrin, cyfluthrin and cypermethrin) by gas chromatography/mass spectrometry. The prevalence and concentration of pesticides in the two matrices were compared.
Prevalence of propoxur was higher in hair compared to house dust (p<0.001) whereas prevalence of the pyrethroids was higher (p<0.001) in house dust. The overall concentrations of the pyrethroids were also higher (p<0.007) in house dust compared to hair. There was a significant (p<0.001) correlation between dust and hair for bioallethrin and cypermethrin.
Ongoing exposure of children to environmental pesticides is sensitively detected by analysis of children's hair and house dust. However, prevalence of propoxur was higher in hair compared to swept house dust, but the opposite was found for the pyrethroids. Thus, both matrices should be analyzed. There was a significant (p<0.001) correlation between house dust and hair for bioallethrin and cypermethrin.
背景/目的：对农药对儿童神经发育的不良影响进行长期研究，不仅需要监测最初的农药暴露情况，还需要监测持续的农药暴露情况。我们的目的是比较家庭灰尘和儿童头发，作为儿童持续接触农药的环境和生物标志物。
设计/方法：在一项美国国立卫生研究院关于产前农药暴露对儿童神经发育不良影响的持续研究中，通过气相色谱/质谱法测量了4岁儿童清扫的家庭灰尘和头发中残杀威和拟除虫菊酯类（七氟菊酯、生物烯丙菊酯、氟氯氰菊酯和氯氰菊酯）出生后的持续农药暴露情况。比较了两种基质中农药的患病率和浓度。
头发中残杀威的患病率高于家庭灰尘（p<0.001），而拟除虫菊酯类在家庭灰尘中的患病率更高（p<0.001）。与头发相比，家庭灰尘中拟除虫菊酯类的总体浓度也更高（p<0.007）。生物烯丙菊酯和氯氰菊酯在灰尘和头发之间存在显著（p<0.001）相关性。
通过分析儿童头发和家庭灰尘可以灵敏地检测到儿童持续接触环境农药的情况。然而，头发中残杀威的患病率高于清扫的家庭灰尘，但拟除虫菊酯类的情况则相反。因此，两种基质都应进行分析。生物烯丙菊酯和氯氰菊酯在家庭灰尘和头发之间存在显著（p<0.001）相关性。
