血浆成分包被的金纳米颗粒对二磷酸腺苷诱导的血小板聚集的影响。

Effect of gold nanoparticles coated with plasma components on ADP-induced platelet aggregation.

作者信息

Aseychev A V, Azizova O A, Beckman E M, Dudnik L B, Sergienko V I

机构信息

Laboratory of Biophysical Bases of Pathology, Research Institute of Physicochemical Medicine, Russian Federal Medical Biological Agency, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2013 Sep;155(5):685-8. doi: 10.1007/s10517-013-2226-x.

DOI:10.1007/s10517-013-2226-x

PMID:24288740

Abstract

We studied the effect of gold nanospheres coated with components of autologous blood plasma on ADP-induced platelet aggregation. Gold nanoparticles in the chosen concentration range (5-40 μM) and particle size (5-30 nm) with or without coating produced no activating effect on platelet aggregation caused by aggregation inductor ADP in all applied doses (1.6, 2.0, and 5.0 μM). Nanoparticles with a diameter of >60 nm inhibited platelet aggregation. These findings and published data confirm the biological safety of gold nanoparticles for targeted delivery of drugs and phototherapy.

摘要

我们研究了涂覆有自体血浆成分的金纳米球对二磷酸腺苷（ADP）诱导的血小板聚集的影响。在选定的浓度范围（5 - 40 μM）和粒径（5 - 30 nm）内，无论有无涂层的金纳米颗粒，对于所有应用剂量（1.6、2.0和5.0 μM）的聚集诱导剂ADP引起的血小板聚集均未产生激活作用。直径>60 nm的纳米颗粒抑制血小板聚集。这些发现和已发表的数据证实了金纳米颗粒在药物靶向递送和光疗方面的生物安全性。