IGZO 薄膜晶体管生物传感器，功能化的 ZnO 纳米棒和抗体。
IGZO thin film transistor biosensors functionalized with ZnO nanorods and antibodies.
机构信息
Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106, Taiwan.
Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, Section 1, Taipei 100, Taiwan; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, No. 1, Jen-Ai Road, Section 1, Taipei 100, Taiwan.
出版信息
Biosens Bioelectron. 2014 Apr 15;54:306-10. doi: 10.1016/j.bios.2013.10.043. Epub 2013 Nov 12.
We demonstrate a biosensor structure consisting of an IGZO (Indium-Gallium-Zinc-Oxide) TFT (thin film transistor) and an extended sensing pad. The TFT acts as the sensing and readout device, while the sensing pad ensures the isolation of biological solution from the transistor channel layer, and meanwhile increases the sensing area. The biosensor is functionalized by first applying ZnO nanorods to increase the surface area for attracting electrical charges of EGFR (epidermal growth factor receptor) antibodies. The device is able to selectively detect 36.2 fM of EGFR in the total protein solution of 0.1 ng/ml extracted from squamous cell carcinoma (SCC). Furthermore, the conjugation duration of the functionalized device with EGFR can be limited to 3 min, implying that the biosensor has the advantage for real-time detection.
我们展示了一种由 IGZO（铟镓锌氧化物）TFT（薄膜晶体管）和扩展传感垫组成的生物传感器结构。TFT 充当传感和读出设备，而传感垫确保生物溶液与晶体管沟道层隔离，同时增加了传感面积。该生物传感器通过首先施加 ZnO 纳米棒来功能化，以增加表面积以吸引 EGFR（表皮生长因子受体）抗体的电荷量。该器件能够选择性地检测来自鳞状细胞癌 (SCC) 的 0.1ng/ml 总蛋白溶液中 36.2fM 的 EGFR。此外，功能化器件与 EGFR 的缀合持续时间可以限制在 3 分钟内，这意味着该生物传感器具有实时检测的优势。
Zotero 插件