School of Electrical and Electronic Engineering, Yonsei University , 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
ACS Appl Mater Interfaces. 2013 Nov 13;5(21):10715-20. doi: 10.1021/am402857w. Epub 2013 Oct 16.
A high-sensitivity, label-free method for detecting deoxyribonucleic acid (DNA) using solution-processed oxide thin-film transistors (TFTs) was developed. Double-crossover (DX) DNA nanostructures with different concentrations of divalent Cu ion (Cu(2+)) were immobilized on an In-Ga-Zn-O (IGZO) back-channel surface, which changed the electrical performance of the IGZO TFTs. The detection mechanism of the IGZO TFT-based DNA biosensor is attributed to electron trapping and electrostatic interactions caused by negatively charged phosphate groups on the DNA backbone. Furthermore, Cu(2+) in DX DNA nanostructures generates a current path when a gate bias is applied. The direct effect on the electrical response implies that solution-processed IGZO TFTs could be used to realize low-cost and high-sensitivity DNA biosensors.
采用溶液处理的氧化物薄膜晶体管（TFT）开发了一种高灵敏度、无标记的脱氧核糖核酸（DNA）检测方法。将不同浓度二价铜离子（Cu(2+)）的双交叉（DX）DNA 纳米结构固定在 In-Ga-Zn-O（IGZO）背沟道表面，从而改变了 IGZO TFT 的电性能。基于 IGZO TFT 的 DNA 生物传感器的检测机制归因于 DNA 主链上带负电荷的磷酸基团引起的电子俘获和静电相互作用。此外，DX DNA 纳米结构中的 Cu(2+)在施加栅极偏压时会产生电流路径。对电响应的直接影响表明，溶液处理的 IGZO TFT 可用于实现低成本、高灵敏度的 DNA 生物传感器。
