Chen X B, Nisbet D R, Li R W, Smith P N, Abbott T B, Easton M A, Zhang D-H, Birbilis N
Department of Materials Engineering, Monash University, VIC 3800, Australia.
Research School of Engineering, The Australian National University, Acton, ACT 0200, Australia; John Curtins School of Medical Research, The Australian National University, Acton, ACT 0200, Australia.
Acta Biomater. 2014 Mar;10(3):1463-74. doi: 10.1016/j.actbio.2013.11.016. Epub 2013 Nov 27.
A simple strontium phosphate (SrP) conversion coating process was developed to protect magnesium (Mg) from the initial degradation post-implantation. The coating morphology, deposition rate and resultant phases are all dependent on the processing temperature, which determines the protective ability for Mg in minimum essential medium (MEM). Coatings produced at 80 °C are primarily made up of strontium apatite (SrAp) with a granular surface, a high degree of crystallinity and the highest protective ability, which arises from retarding anodic dissolution of Mg in MEM. Following 14 days' immersion in MEM, the SrAp coating maintained its integrity with only a small fraction of the surface corroded. The post-degradation effect of uncoated Mg and Mg coated at 40 and 80 °C on the proliferation and differentiation of human mesenchymal stem cells was also studied, revealing that the SrP coatings are biocompatible and permit proliferation to a level similar to that of pure Mg. The present study suggests that the SrP conversion coating is a promising option for controlling the early rapid degradation rate, and hence hydrogen gas evolution, of Mg implants without adverse effects on surrounding cells and tissues.
开发了一种简单的磷酸锶（SrP）转化涂层工艺，以保护镁（Mg）在植入后免受初期降解。涂层的形态、沉积速率和生成的相均取决于加工温度，而加工温度决定了其在最低基本培养基（MEM）中对镁的保护能力。在80°C下制备的涂层主要由具有颗粒状表面、高结晶度和最高保护能力的锶磷灰石（SrAp）组成，这种保护能力源于其延缓了镁在MEM中的阳极溶解。在MEM中浸泡14天后，SrAp涂层保持完整，只有一小部分表面被腐蚀。还研究了未涂层的镁以及在40°C和80°C下涂层的镁在降解后对人间充质干细胞增殖和分化的影响，结果表明SrP涂层具有生物相容性，其增殖水平与纯镁相似。本研究表明，SrP转化涂层是控制镁植入物早期快速降解速率以及由此产生的氢气释放的一种有前景的选择，且对周围细胞和组织无不良影响。
