Department of Oral Health Sciences, Faculty of Dentistry, The University of British Columbia, RM 374, 2199 Wesbrook Mall, Vancouver, BC, V6T1Z3, Canada,
Drugs Aging. 2014 Jan;31(1):55-65. doi: 10.1007/s40266-013-0141-5.
Over three-quarters of the older population take medications that can potentially cause dry mouth. Physicians or pharmacists rarely inform patients about this adverse effect and its potentially severe damage to the teeth, mouth and general health.
The objectives of this study were to (1) identify warnings in the literature about dry mouth associated with the most frequently prescribed pharmaceutical products in Canada; and (2) consider how this information might be obtained by physicians, pharmacists and patients.
Monographs on the 72 most frequently prescribed medications during 2010 were retrieved from the Compendium of Pharmaceuticals and Specialties (CPS, a standard drug information reference for physicians and pharmacists), the National Library of Medicine's 'DailyMed' database, directly from the manufacturers, and from a systematic search of biomedical journals.
The CPS provided monographs for 43% of the medications, and requests to manufacturers produced the remaining monographs. Mentions of dry mouth were identified in 61% of the products (43% amongst CPS monographs; an additional 43% amongst manufacturers' monographs; 7% in the DailyMed database and 7% from biomedical journals); five medications had contradictory reports in different monographs.
Nearly two-thirds (61%) of the most commonly prescribed medications can cause dry mouth, yet warnings about this adverse effect and its potentially serious consequences are not readily available to physicians, pharmacists, dentists or patients.
超过四分之三的老年人服用可能导致口干的药物。医生或药剂师很少向患者告知这种不良反应及其对口、牙齿和整体健康的潜在严重损害。
本研究的目的是：（1）在与加拿大最常开处方的药物相关的文献中确定有关口干的警告信息；（2）考虑医生、药剂师和患者如何获取这些信息。
从 Compendium of Pharmaceuticals and Specialties（CPS，医生和药剂师的标准药物信息参考）、美国国家医学图书馆的 DailyMed 数据库、直接从制造商处以及对生物医学期刊的系统搜索中检索了 2010 年最常开处方的 72 种药物的专论。
CPS 提供了 43%的药物专论，向制造商的请求产生了其余的药物专论。在 61%的产品中发现了口干的提及（CPS 专论中有 43%；制造商专论中另外有 43%；DailyMed 数据库中有 7%，生物医学期刊中有 7%）；五种药物在不同的专论中有相互矛盾的报告。
近三分之二（61%）的最常用药物可能导致口干，但关于这种不良反应及其潜在严重后果的警告信息并不容易为医生、药剂师、牙医或患者获得。
