特发性肺动脉高压患者血清尿酸水平与心室功能的关系
Relationship between serum uric acid levels and ventricular function in patients with idiopathic pulmonary hypertension.
作者信息
Zhang Chun-Yan, Ma Long-Le, Wang Le-Xin
机构信息
Department of Cardiac Surgery, Liaocheng People's Hospital of Taishan Medical University, Liaocheng, Shandong, People's Republic of China;
出版信息
Exp Clin Cardiol. 2013 Winter;18(1):e37-9.
OBJECTIVE
To investigate the relationship between serum uric acid levels and pulmonary hypertension in patients with idiopathic pulmonary artery hypertension (IPAH).
METHODS
Serum uric acid levels were measured in 86 patients (mean [± SD] age 35.2±12.3 years; 36 men) with IPAH. Pulmonary arterial pressure and ventricular function were assessed using echocardiography. Serum uric acid levels were also measured in 40 healthy subjects (35.9±11.6 years of age; 15 men).
RESULTS
Serum uric acid levels in IPAH patients were higher compared with control subjects (405±130 μmol/L versus 344±96 μmol/L; P<0.05). Fifty-two (60.4%) of the 86 patients with IPAH had elevated serum uric acid levels. The pulmonary systolic pressure and mean pulmonary pressure in the high uric acid group were higher than in the normal uric acid group (P<0.05). The left and right ventricular ejection fractions were lower in the high uric acid group compared with the normal uric acid group (P<0.05). Serum uric acid levels were correlated with the mean pulmonary arterial pressure (r=0.387; P<0.01) and New York Heart Association class (r=0.41; P<0.01). There was also an inverse correlation between uric acid levels and the left (r=-0.550; P<0.01) and right ventricular ejection fractions (r=-0.481; P<0.05).
CONCLUSION
Serum uric acid levels are associated with IPAH severity and the severity of ventricular dysfunction.
目的
探讨特发性肺动脉高压（IPAH）患者血清尿酸水平与肺动脉高压之间的关系。
方法
测定86例IPAH患者（平均[±标准差]年龄35.2±12.3岁；36例男性）的血清尿酸水平。采用超声心动图评估肺动脉压和心室功能。还测定了40名健康受试者（年龄35.9±11.6岁；15例男性）的血清尿酸水平。
结果
IPAH患者的血清尿酸水平高于对照组（405±130μmol/L对344±96μmol/L；P<0.05）。86例IPAH患者中有52例（60.4%）血清尿酸水平升高。高尿酸组的肺动脉收缩压和平均肺动脉压高于正常尿酸组（P<0.05）。高尿酸组的左、右心室射血分数低于正常尿酸组（P<0.05）。血清尿酸水平与平均肺动脉压（r=0.387；P<0.01）和纽约心脏协会分级（r=0.41；P<0.01）相关。尿酸水平与左心室射血分数（r=-0.550；P<0.01）和右心室射血分数（r=-0.481；P<0.05）也呈负相关。
结论
血清尿酸水平与IPAH严重程度及心室功能障碍严重程度相关。
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