Cornblath D R, Griffin J W, Tennekoon G I
Ann Neurol. 1986 Sep;20(3):370-2. doi: 10.1002/ana.410200319.
The presence of myelin basic protein (MBP)-like material in cerebrospinal fluid (CSF) usually reflects breakdown of central nervous system myelin. Immunoreactive MBP levels were measured in 70 CSF specimens from 66 patients with a variety of peripheral neuropathies. Immunoreactive MBP was present in CSF in 70% (16 of 23) of patients with biopsy-proved chronic demyelinating polyneuropathies, whereas in neuropathies producing primarily axonal damage it was present in only 22% (5 of 23). In Guillain-Barré syndrome, 45% (9 of 20) of patients had immunoreactive MBP in the CSF. We conclude that MBP-like material is present in the CSF of most patients with longstanding demyelinating polyradiculoneuropathies and probably reflects detection of peripheral nervous system P1 protein.
脑脊液（CSF）中髓鞘碱性蛋白（MBP）样物质的存在通常反映中枢神经系统髓鞘的破坏。对66例患有各种周围神经病的患者的70份脑脊液标本进行了免疫反应性MBP水平检测。经活检证实为慢性脱髓鞘性多发性神经病的患者中，70%（23例中的16例）脑脊液中存在免疫反应性MBP，而主要产生轴突损伤的神经病患者中，只有22%（23例中的5例）脑脊液中存在免疫反应性MBP。在格林-巴利综合征中，45%（20例中的9例）患者脑脊液中有免疫反应性MBP。我们得出结论，大多数长期脱髓鞘性多发性神经根神经病患者的脑脊液中存在MBP样物质，这可能反映了对周围神经系统P1蛋白的检测。
