复制偶联 DNA 修复。
Replication-Coupled DNA Repair.
机构信息
Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
出版信息
Mol Cell. 2019 Jun 6;74(5):866-876. doi: 10.1016/j.molcel.2019.04.027.
Abstract
The replisome quickly and accurately copies billions of DNA bases each cell division cycle. However, it can make errors, especially when the template DNA is damaged. In these cases, replication-coupled repair mechanisms remove the mistake or repair the template lesions to ensure high fidelity and complete copying of the genome. Failures in these genome maintenance activities generate mutations, rearrangements, and chromosome segregation problems that cause many human diseases. In this review, I provide a broad overview of replication-coupled repair pathways, explaining how they fix polymerase mistakes, respond to template damage that acts as obstacles to the replisome, deal with broken forks, and impact human health and disease.
摘要
复制体在每个细胞分裂周期中快速而准确地复制数十亿个 DNA 碱基。然而，它也会出错，尤其是当模板 DNA 受到损伤时。在这些情况下，复制偶联修复机制会清除错误或修复模板损伤，以确保基因组的高保真度和完整复制。这些基因组维护活动的失败会产生突变、重排和染色体分离问题，从而导致许多人类疾病。在这篇综述中，我提供了一个关于复制偶联修复途径的广泛概述，解释了它们如何修复聚合酶错误，应对作为复制体障碍的模板损伤，处理断裂的叉，并影响人类健康和疾病。
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