钙拮抗剂对大鼠腹膜肥大细胞过敏和非过敏组胺分泌的抑制作用。
Inhibition of allergic and non-allergic histamine secretion from rat peritoneal mast cells by calcium antagonists.
作者信息
Chand N, Diamantis W, Pillar J, Sofia R D
出版信息
Br J Pharmacol. 1984 Dec;83(4):899-902. doi: 10.1111/j.1476-5381.1984.tb16529.x.
Abstract
Bepridil, TMB-8 (8-(diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride), diltiazem, verapamil and nifedipine exerted concentration-dependent inhibition of antigen and calcium ionophore A23187-induced histamine release from rat peritoneal mast cells. The inhibitory effects of verapamil and bepridil against calcium ionophore A23187-induced histamine secretion were antagonized by increased Ca2+ concentrations in the extracellular medium. These observations suggest that both agents act by interfering with the influx of Ca2+ into the mast cells. The inhibitory activities of five different Ca2+ channel blockers on allergic and non-allergic histamine secretion from rat peritoneal mast cells varied considerably depending upon the nature of the secretagogue as well as concentration and type of Ca2+-antagonist examined.
摘要
苄普地尔、TMB - 8（盐酸8 - （二乙氨基）辛基3,4,5 - 三甲氧基苯甲酸酯）、地尔硫䓬、维拉帕米和硝苯地平对大鼠腹膜肥大细胞抗原及钙离子载体A23187诱导的组胺释放具有浓度依赖性抑制作用。细胞外培养基中Ca2 +浓度升高可拮抗维拉帕米和苄普地尔对钙离子载体A23187诱导的组胺分泌的抑制作用。这些观察结果表明，这两种药物都是通过干扰Ca2 +流入肥大细胞而发挥作用的。五种不同的Ca2 +通道阻滞剂对大鼠腹膜肥大细胞过敏性和非过敏性组胺分泌的抑制活性因促分泌剂的性质以及所检测的Ca2 +拮抗剂的浓度和类型不同而有很大差异。
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